English: Diagram of how microtubules desintegrate with Alzheimer’s disease Français : La protéine Tau dans un neurone sain et dans un neurone malade Español: Esquema que muestra cómo se desintegran los microtúbulos en la enfermedad de Alzheimer (Photo credit: Wikipedia)
Mechanism uncovered could also help preserve neuron function in Alzheimer’s disease, traumatic brain injury and other neurodegenerative conditions
Research presented by Dr. Lynn Raymond, from the University of British Columbia, shows that blocking a specific class of glutamate receptors, called extrasynaptic NMDA receptors, can improve motor learning and coordination, and prevent cell death in animal models of Huntington disease. As Huntington disease is an inherited condition that can be detected decades before any clinical symptoms are seen in humans, a better understanding of the earliest changes in brain cell (neuronal) function, and the molecular pathways underlying those changes, could lead to preventive treatments that delay the onset of symptoms and neurodegeneration. “After more than a decade of research on the pre-symptomatic phase of Huntington disease, markers are being developed to facilitate assessment of interventional therapy in individuals carrying the genetic mutation for Huntington disease, before they become ill. This will make it possible to delay onset of disease,” says Dr. Raymond.
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The Latest on: Huntington’s disease
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The Latest on: Huntington’s disease
- New therapeutic target for Huntington's treatmenton February 23, 2021 at 4:41 am
Huntington's disease is caused by a mutation in the Huntingtin gene (HTT), which appears in adults and features motor, cognitive and psychiatric alterations. The origin of this disease has been ...
- Basic cell health systems wear down in Huntington's disease, novel analysis showson February 23, 2021 at 1:46 am
Using an innovative computational approach to analyze vast brain cell gene expression datasets, researchers at MIT and Sorbonne Université have found that Huntington's disease may progress to advanced ...
- Lost Huntington: ‘Catfish’ Grayon February 22, 2021 at 9:00 pm
The late Lawrence Fredrick Gray — better known as “Catfish, Man of the Woods” — was a well-known local herbalist and folk doctor who gained national attention. Featured in several documentary films, ...
- Allie LaForce, Joe Smith share family’s story to help others in fight against Huntington’s diseaseon February 22, 2021 at 4:33 pm
A local couple is sharing their own family’s journey with Huntington’s disease in hopes of helping others battling the illness. Former FOX 8 personality and ...
- How Coronavirus Is Affecting Huntington Area Nursing Homes: Weekly Updateon February 19, 2021 at 3:34 pm
The federal government is tracking the decline of COVID-19 cases in nursing homes, including in the Huntington area.
- Normalising life at risk of Huntington’s disease. A qualitative study of backgrounds and coping strategies of fears of genetic discriminationon February 16, 2021 at 10:59 am
Studies in the sociology of genetics have shown how living with a predisposition to a genetic disorder often comes with significant psycho-social burdens and struggles. One of these struggles is the ...
- Revealed protein structure could aid in Huntington’s disease treatment developmenton February 15, 2021 at 4:40 am
Researchers have partially observed the structure of heat shock proteins that bind to proteins that cause Huntington's disease.
- Research provides insight into protein structures that could treat Huntington’s diseaseon February 14, 2021 at 4:38 pm
In Huntington's disease, a faulty protein aggregates in brain cells and eventually kills them. Such protein aggregates could, in principle, be prevented with a heat shock protein. However, it is not ...
- Officials seek public comments on potential new Ohio medical marijuana conditions – from Huntington’s disease to restless leg syndromeon February 12, 2021 at 9:12 am
AState Medical Board of Ohio committee chose six conditions to further look at from around 30 petitions that members of the public had quested be added to the Ohio medical marijuana list of qualifying ...
- Study addresses multiple challenges of the pathogenesis of Huntington's diseaseon February 11, 2021 at 9:18 pm
Recent genetic data from patients with Huntington's disease (HD) show that DNA repair is an important factor that determines how early or late the disease occurs in individuals who carry the expanded ...
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