Scientists at The University of Nottingham have developed a new substance which could simplify the manufacture of cell therapy in the pioneering world of regenerative medicine.
Cell therapy is an exciting and rapidly developing area of medicine in which stem cells have the potential to repair human tissue and maintain organ function in chronic disease and age-related illnesses. But a major problem with translating current successful research into actual products and treatments is how to mass-produce such a complex living material.
There are two distinct phases in the production of stem cell products; proliferation (making enough cells to form large tissue) and differentiation (turning the basic stem cells into functional cells). The material environment required for these two phases are different and up to now a single substance that does both jobs has not been available.
Now a multi-disciplinary team of researchers at Nottingham has created a new stem cell micro-environment which they have found has allowed both the self-renewal of cells and then their evolution into cardiomyocyte (heart) cells. The material is a hydrogel containing two polymers – an alginate-rich environment which allows proliferation of cells with a simple chemical switch to render the environment collagen-rich when the cell population is large enough. This change triggers the next stage of cell growth when cells develop a specific purpose.
Professor of Advanced Drug Delivery and Tissue Engineering, Kevin Shakesheff, said:
“Our new combination of hydrogels is a first. It allows dense tissue structures to be produced from human pluripotent stem cells (HPSC) in a single step process never achieved before. The discovery has important implications for the future of manufacturing in regenerative medicine. This field of healthcare is a major priority for the UK and we are seeing increasing investment in future manufacturing processes to ensure we are ready to deliver real treatments to patients when HPSC products and treatments go to trial and become standard.”
The Latest on: Stem cell manufacturing
[google_news title=”” keyword=”Stem cell manufacturing” num_posts=”10″ blurb_length=”0″ show_thumb=”left”]
via Google News
The Latest on: MStem cell manufacturing
- Proterra Inc.: Proterra Congratulates LG Energy Solution on Announcement of Arizona Battery Manufacturing Complexon March 24, 2023 at 2:37 pm
The two companies previously announced a long-term supply agreement for cylindrical cells manufactured at a LG Energy Solution U.S. facility The Manufacturing Complex is expected to include dedicated ...
- Surge of clean energy manufacturing projects in Texas, U.S.on March 24, 2023 at 10:48 am
Still, China controls 60 percent of the manufacturing capacity for renewable energy equipment ... The actual silicon-based solar cells that convert sunlight into energy will be imported from Indonesia ...
- Ford is Readying High-Volume Electric Pickup Manufacturingon March 24, 2023 at 9:03 am
Ford’s F-150 Lightning electric pickup has won accolades, but the truck is simply too expensive and time-consuming to build at the volume of Ford’s best-selling combustion-powered F-150 trucks. Ford’s ...
- Stem Cell Banking Storage Market Top Players by 2031on March 24, 2023 at 6:16 am
The "Stem Cell Banking Storage Market" study describes how the technology industry is evolving and how major and ...
- Hanwha, QCells to deepen manufacturing presence in Georgia with solar encapsulant planton March 24, 2023 at 5:05 am
Hanwha Advanced Materials will increase its investment in the US state of Georgia to support the QCells' PV manufacturing plans.
- Hanwha unit to build solar panel material factory for supply to Q Cellson March 23, 2023 at 11:32 pm
Hanwha Advanced Materials Inc., a unit under South Korea's energy-to-defense Hanwha Group, will spend US$147 million to build a facility in the U.S. state of Georgia to supply a key material to Hanwha ...
- Tucson courting high-value manufacturing jobson March 22, 2023 at 7:00 am
Tucson-area business and government leaders are focused on growing manufacturing jobs, citing relatively high pay and economic impact.
- Stem Cell Manufacturing Market to Hit USD 26.6 Bn Valuation by 2033 Due to Rising Demand for Cell Treatments | TMRon March 21, 2023 at 12:30 pm
Top/Emerging companies operating in the global stem cell manufacturing industry are Thermo Fisher Scientific, Merck Millipore, Lonza Group AG, Danaher Corporation, Sartorius AG, Bio-Rad Laboratories, ...
- FDA Schedules Pre-License Inspection of Remestemcel-L Manufacturingon March 20, 2023 at 5:00 pm
Mesoblast Limited (ASX:MSB; Nasdaq:MESO), global leader in allogeneic cellular medicines for inflammatory diseases, today announced that, as part of the ongoing review of the BLA for remestemcel-L in ...
- Transcript: Bringing It Home: Manufacturingon March 20, 2023 at 2:53 pm
LYNCH: I wanted to ask you also about what seems to be something of a tension between your manufacturing goals, on the one hand, promoting domestic manufacturing, and the climate imperative, on the ...
via Bing News