This discovery represents a major innovation
Researchers from the University of California, San Diego Skaggs School of Pharmacy and Pharmaceutical Sciences, in collaboration with materials scientists, engineers and neurobiologists, have discovered a new mechanism for using light to activate drug-delivering nanoparticles and other targeted therapeutic substances inside the body.
This discovery represents a major innovation, said Adah Almutairi, PhD, associate professor and director of the joint UC San Diego-KACST Center of Excellence in Nanomedicine. Up to now, she said, only a handful of strategies using light-triggered release from nanoparticles have been reported.
The mechanism, described in the April 1, 2014 online issue of ACS Nano, employs near-infrared (NIR) light from a low-power laser to heat pockets of water trapped within non-photo-responsive polymeric nanoparticles infused with drugs. The water pockets absorb the light energy as heat, which softens the encapsulating polymer and allows the drug to be released into the surrounding tissue. The process can be repeated multiple times, with precise control of the amount and dispersal of the drug.
“A key advantage of this mechanism is that it should be compatible with almost any polymer, even those that are commercially available,” said Mathieu Viger, a post-doctoral fellow in Almutairi’s laboratory and co-lead author of the study. “We’ve observed trapping of water within particles composed of all the biodegradable polymers we’ve so far tested.”
The method, noted Viger, could thus be easily adopted by many biological laboratories.
The combined use of hydrated polymers and near-infrared light appears to resolve a host of technological and health barriers that have hindered previous, similar approaches. Earlier efforts to use NIR-triggered release have not been widely exploited because they required special designer polymers, expensive high-powered lasers and/or the co-encapsulation of inorganic particles whose safety in the body remains questionable.
The new method described by Almutairi and colleagues in the departments of Mechanical and Aerospace Engineering, Neuroscience, and Chemistry and Biochemistry at UC San Diego uses NIR at a vibrational wavelength cued to excite water molecules, which absorb the optical energy and convert it to heat. NIR is capable of penetrating biological tissues to greater depths than visible or ultraviolet light.
Co-lead author Wangzhong Sheng, a graduate student in Department of Mechanical and Aerospace Engineering, explained the selectivity of heating by comparing the trapped water within particles to a glass of water and the surrounding water within the solution or tissue to a bathtub. The smaller amount of water is heated much more rapidly because of the enormous volume difference.
An obvious use of the method, said Almutairi, is light-triggered drug delivery, but with more research, she anticipates the new method could provide a variety of industrial, medical and scientific applications, including “any technological application requiring that chemistry be controlled in time and in space, such as in catalysis or self-repairing materials or light-activated sunscreens or pesticide dosing.”
The Latest on: Drug delivery
via Google News
The Latest on: Drug delivery
- Aquestive Therapeutics to Host Investor & Analyst Virtual Epinephrine Drug Delivery R&D ...on March 4, 2021 at 8:02 pm
Aquestive Therapeutics, Inc. (NASDAQ: AQST), a pharmaceutical company focused on developing and commercializing differentiated products that address patients’ unmet needs and solve therapeutic ...
- Drug Delivery Market to Reach USD 1,792.60 billion by 2026 | Fortune Business Insights™on March 3, 2021 at 11:13 am
The globaldrug delivery market trendsis forecasted to reach USD 1,792.60 billion by 2026, attributable to the rapid development of the pharmaceutical industry and the advent of drug delivery systems ...
- Global Needle-Free Drug Delivery Systems Market Outlook, Industry Analysis and Prospect 2018-2025on March 3, 2021 at 1:14 am
Global Needle Free Drug Delivery Device Market OverviewNeedle-free drug delivery device provides a solution to deliver ...
- Lexaria Bioscience Corp. is Changing the Future of Drug Deliveryon March 2, 2021 at 6:44 pm
Lexaria Bioscience Corp. (NASDAQ: LEXX) is developing emerging technology that promotes faster delivery of drugs into the bloodstream, among other patented innovative health initiatives, making the ...
- Youngwood man to remain in jail to await drug delivery resulting in death trialon March 2, 2021 at 1:30 pm
A Youngwood man will remain in jail to await trial on a charge that he delivered drugs to a woman who died from an overdose in August 2019. Matthew Thomas Caughey pleaded for his release during a cour ...
- Computational modelling of nanotube delivery of anti-cancer drug into glutathione reductase enzymeon March 2, 2021 at 8:48 am
Density functional theory method combined with docking and molecular dynamics simulations are used to understand the interaction of carmustine with human glutathione reductase enzyme. The active site ...
- ScPharmaceuticals plots refiling of twice-rejected on-body drug delivery producton March 2, 2021 at 7:34 am
The company expects to be ready to refile once it has completed work including modified bench tests on aged commercial units of its on-body drug delivery system. Furoscix is designed to give patients ...
- Global Connected Drug Delivery Devices (Bluetooth, NFC, Other) Market Size, Share & Trends Analysis Report 2021-2028 - ResearchAndMarkets.comon March 1, 2021 at 9:35 pm
ResearchAndMarkets.com The “Connected Drug Delivery Devices Market Size, Share & Trends Analysis Report by Technology (Bluetooth, NFC), by Product (Connected Sensors, Integrated Connected Devices), by ...
- Beam Therapeutics Adds To Drug Delivery With $120M GuideTx Buyon February 23, 2021 at 5:47 pm
Beam Therapeutics Inc (NASDAQ: BEAM) acquires Guide Therapeutics (GuideTx), a developer of nonviral drug delivery vehicles for genetic medicines, in an all-stock deal for $120 million upfront. GuideTx ...
- Beam Therapeutics acquires a biotech focused on drug deliveryon February 23, 2021 at 2:53 pm
The Cambridge-based gene editing company is acquiring Georgia Tech spinout Guide Therapeutics for $120 million upfront.
via Bing News