Researchers at Griffith University‘s Eskitis Institute have developed a new technique for discovering natural compounds which could form the basis of novel therapeutic drugs. The Parkinson’s response is just the start.
The corresponding author, Professor Ronald Quinn AM said testing the new process on a marine sponge had delivered not only confirmation that the system is effective, but also a potential lead in the fight against Parkinson’s disease.
“We have found a new screening method which allows us to identify novel molecules drawn from nature to test for biological activity,” Professor Quinn said.
“As it happens, the first new compound we discovered through this process has demonstrated a response in Parkinson’s disease cells.”
Prestigious chemistry journal Angewandte Chemie has published the results in “NMR Fingerprints of the Drug-like Natural Product Space: Iotrochotazine A, a Chemical Probe to Study Parkinson’s Disease”.
The first author Dr Tanja Grkovic said the screening process involves nuclear magnetic resonance (NMR) spectroscopy; a highly sensitive instrument through which it is possible to see natural products weighing as little as 20 micrograms, which is less than a grain of salt.
“When you are searching for nature-derived molecules, the jackpot is finding something that nobody has ever seen before and rather than just a variation on a known theme,” Dr Grkovic said.
“We began the project by selecting 20 marine sponge samples randomly from Griffith’s Nature Bank facility and using the NMR technique trying to visualise all the small molecules which could meet the requirements for a potential new drug.
“The idea was to look at patterns of data and identify unusual or unique sets. We followed one such pattern and isolated a natural product with a novel skeleton which has turned out to be a molecule which was completely unknown previously.”
Griffith’s Nature Bank is a unique drug discovery resource based on natural products found in Australia, China and Papua New Guinea. It comprises more than 45,000 samples of plants and marine invertebrates, 200,000 semi-purified fractions, 3,250 pure compounds and over 600 naturally-occurring fragments.
This NMR screening process provides a new way of searching all those natural samples stored in Nature Bank and uncovering the potential biological activity of the compounds within them.
Deputy Director of the Eskitis Institute and co-author of the paper, Associate Professor George Mellick, is a specialist researcher in neurodegenerative diseases such as Parkinson’s disease. He is delighted by the research prospects this new molecule may provide.
“What is very intriguing about this novel natural product is that, while we have found it has an effect on cells sourced from a Parkinson’s patient, it showed a different biological activity on cells from healthy individuals,” Associate Professor Mellick said.
“This provides us with a new tool to study the fundamental biology of Parkinson’s and to get a better understanding of the cellular processes involved in the development of this disease.
But the Parkinson’s response is just the start.
“This new research technique opens the door to unlimited opportunities, both in terms of chemistry and biology research at Eskitis, as we continue the search for new therapies against disease,” Professor Quinn said.
The Latest on: New drugs from nature
via Google News
The Latest on: New drugs from nature
- Sunitinib treatment promotes metastasis of drug-resistant renal cell carcinoma via TFE3 signaling pathwayon February 26, 2021 at 10:02 am
Renal cell carcinoma (RCC) accounts for approximately 2% of all adult malignancies worldwide 1. Clear cell renal cell carcinoma (ccRCC), the most common histologic subtype of RCC 2, is characterized ...
- Drug Pricing Policy Must Prioritize Patientson February 26, 2021 at 9:32 am
I am concerned that federal and state policymakers continue to reference ICER as they look to lower the cost of drugs.
- A New Realm of Drug Discovery Utilizing Ubiquitin Ligaseon February 26, 2021 at 2:14 am
UNLV scientist Gary Kleiger is at the forefront of a potential new drug modality; research published in the journal Nature.
- Ural federal university: New Synthesis Method Developed at UrFU Could Facilitate Production of Anticancer Drugson February 26, 2021 at 1:20 am
Chemists of the Ural Federal University have developed a simple and highly efficient method for the targeted synthesis of a wide range of new substances. It is potentially useful for the production of ...
- New device accelerates transdermal penetration of drug molecules and extraction of interstitial fluidon February 25, 2021 at 9:44 pm
A pain-free, organic and biodegradable drug delivery patch may be on the horizon for home health care patients soon.
- New approach harnesses disease-causing proteins to combat canceron February 25, 2021 at 9:31 pm
Over many decades now, traditional drug discovery methods have steadily improved at keeping diseases at bay and cancer in remission. And for the most part, it's worked well.
- New molecule could be potential drug candidate for Alzheimer’son February 25, 2021 at 7:06 pm
The team led by professor T Govindaraju is confident that the molecule, christened TGR63, could be a potential drug candidate to halt or cure the leading cause of dementia. “We are preparing for ...
- Thin Film Drugs Market Global Sales Are Expected To Reach US$ 43.18 Billion by 2030, as stated by insightSLICEon February 25, 2021 at 7:05 am
The Global Thin Film Drugs Market Share, Trends, Analysis and Forecasts, 2020-2030 provides insights on key developments, business strategies, research & development activities, supply chain analysis, ...
- New Study from UCSD Shows That Chromosome Shattering Can Promote Cancer Cell Growth and Increase Resistance to Chemotherapeutic Drugson February 24, 2021 at 1:45 am
New study shows that chromothripsis (chromosome shattering) can promote cancer cell growth and increase resistance to chemotherapeutic drugs.
- New obesity drug can cut weight down by 20 percenton February 23, 2021 at 6:45 am
A new anti-obesity drug is set to be released. The results have been described as a 'gamechanger'. The new medication is appears to be capable of cutting body weight down by up to 20 percent.
via Bing News