They say that the model has the potential of reducing the need for some animal testing of new drugs for respiratory conditions.
To determine whether new medicines are safe and effective for humans, researchers must first test them in animals, which is costly and time-consuming, as well as ethically challenging. In a study published in ACS’ journal Molecular Pharmaceutics, scientists report that they’ve developed a simple, “3D” laboratory method to test asthma and allergy medications that mimics what happens in the body, which could help reduce the need for animal testing.
Amir Ghaemmaghami and colleagues note that respiratory conditions, such as asthma and allergies, are becoming more common. These conditions affect the lungs and the airway leading to the lungs, making it difficult to breathe. Every year, respiratory symptoms lead to expensive hospital visits, as well as absences from work and school. Better drugs could provide relief, but before giving new medicines to people, researchers must first test them in animals — a costly and laborious process. Sometimes, researchers will use “2D” tests in which they apply the drug to a layer of human cells in a lab dish instead, but this isn’t an adequate way to tell how a medicine will work in a whole animal or a whole person. So, Ghaemmaghami’s team developed a new, 3D alternative.
Their test includes three types of human cells that are typically in a person’s airway. In the body, these cells are close together and are involved in the development of respiratory conditions. The 3D “model” reacted just like a real person’s airway when they exposed it to allergens and bacterial extract. They say that the model has the potential of reducing the need for some animal testing of new drugs for respiratory conditions.
The Latest on: Testing asthma and allergy medications
via Google News
The Latest on: Testing asthma and allergy medications
- Latex Allergy Market Growth Outlook, Future Trends, Share Analysis, Business Overview and COVID-19 Impact Analysis By 2022on January 18, 2021 at 5:16 pm
The global latex allergy market is expected to grow with a steady CAGR during the forecast period (2016-2022), claims Market Research Future (MRFR) in a well-studied report. Exposure to substances ...
- Lipid biomarkers in urine can determine the type of asthmaon January 13, 2021 at 8:21 am
In a new study, researchers have used a urine test to identify and verify a patient's type of asthma. The study lays the foundation for a more personalized diagnosis and may result in improved ...
- Researchers use urine test to identify and verify a patient's type of asthmaon January 13, 2021 at 4:49 am
In a new study, researchers at Karolinska Institutet in Sweden have used a urine test to identify and verify a patient's type of asthma.
- Allergy Skin Test Market 2021- Global Forecasts, Analysis, Company Profiles, Competitive Landscape And Key Regions 2023on January 12, 2021 at 7:27 pm
Skin test for allergies is an easy method by which individuals determine the allergen which is the cause for the reaction. The rising level of awareness about allergies and the availability of ...
- Asthma and Pregnancy: A Reviewon January 2, 2021 at 4:00 pm
Division of Allergy ... asthma type and severity, and initiation of appropriate treatment. The evaluation should include history, physical examination, spirometry measurement, and laboratory ...
- Childhood Asthmaon January 1, 2021 at 2:12 pm
Tests may not be able to confirm asthma in children younger ... how to avoid triggers, what medications do, and how to give treatments. Allergy & Asthma Network: Mothers of Asthmatics: "School ...
- Breathing Problemson December 14, 2020 at 6:49 pm
Other tests include: Allergy blood tests (called a RAST ... allergens and may ease some breathing problems. For asthma, inhaled or oral drugs help open airways and fight inflammation.
- Predictors of Inappropriate and Excessive Use of Reliever Medications in Asthmaon November 25, 2020 at 4:00 pm
having received pulmonary function test in the previous year, visited a specialist in the previous year, and the use of inhaled corticosteroids in the previous year. An asthma-related outpatient ...
- Coronavirus and Asthmaon August 16, 2020 at 11:19 pm
“For those with asthma worried about COVID-19, please do not stop taking your controller medications,” says Dr. Mitchell Grayson, a professor of pediatrics and chief of the division of allergy ...
- Montefiore AERD and Drug Allergy Centeron August 13, 2020 at 4:48 pm
The AERD and Drug Allergy Center offers tests to correctly diagnose whether or not a patient ... has a strong association with other immune-mediated comorbidities including asthma, atopy, and allergy.
via Bing News
