Immunizations could be administered within minutes where and when a disease is breaking out.
Vaccines combat diseases and protect populations from outbreaks, but the life-saving technology leaves room for improvement. Vaccines usually are made en masse in centralized locations far removed from where they will be used. They are expensive to ship and keep refrigerated and they tend to have short shelf lives.
University of Washington engineers hope a new type of vaccine they have shown to work in mice will one day make it cheaper and easy to manufacture on-demand vaccines for humans. Immunizations could be administered within minutes where and when a disease is breaking out.
“We’re really excited about this technology because it makes it possible to produce a vaccine on the spot. For instance, a field doctor could see the beginnings of an epidemic, make vaccine doses right away, and blanket vaccinate the entire population in the affected area to prevent the spread of an epidemic,” said François Baneyx, a UW professor of chemical engineering and lead author of a recent paper published online in the journal Nanomedicine.
In typical vaccines, weakened pathogens or proteins found on the surface of microbes and viruses are injected into the body along with compounds called adjuvants to prepare a person’s immune system to fight a particular disease. But standard formulations don’t always work, and the field is seeking ways to manufacture vaccines quicker, cheaper and tailored to specific infectious agents, Baneyx said.
The UW team injected mice with nanoparticles synthesized using an engineered protein that both mimics the effect of an infection and binds to calcium phosphate, the inorganic compound found in teeth and bones. After eight months, mice that contracted the disease made threefold the number of protective “killer” T-cells – a sign of a long-lasting immune response – compared with mice that had received the protein but no calcium phosphate nanoparticles.
The nanoparticles appear to work by ferrying the protein to the lymph nodes where they have a higher chance of meeting dendritic cells, a type of immune cell that is scarce in the skin and muscles, but plays a key role in activating strong immune responses.
In a real-life scenario, genetically engineered proteins based on those displayed at the surface of pathogens would be freeze-dried or dehydrated and mixed with water, calcium and phosphate to make the nanoparticles. This should work with many different diseases and be especially useful for viral infections that are hard to vaccinate against, Baneyx said.
He cautioned, however, that it has only been proven in mice, and the development of vaccines using this method hasn’t begun for humans.
The Latest on: Vaccines
via Google News
The Latest on: Vaccines
- Pop-up clinic in Phoenix on Saturday to have free COVID-19 tests, vaccines and protective gearon January 26, 2022 at 3:35 am
A pop-up clinic in Phoenix on Saturday will have free COVID-19 tests and vaccines, as well as protective gear to help curb the spread of the virus.
- Myth busters: Frozen pizza, tons and tons of other things more danger than COVID vaccineson January 26, 2022 at 3:30 am
No amount of logic can convince the staunchly unvaccinated, but the risk and benefit calculus heavily favors vaccination, write two researchers.
- Abcarian: Should kids need parental consent for vaccines? Read this before you decideon January 26, 2022 at 3:05 am
Should children as young as 12 be allowed to get vaccinated without their parents’ knowledge or consent? I was taken aback when I read that state Sen. Scott Wiener has proposed a bill that would ...
- Eric Clapton calls critics ‘monsters’ and insists he’s ‘freedom of choice’ rather than anti or pro vaccineson January 26, 2022 at 2:59 am
Eric Clapton has branded critics of his controversial remarks about vaccines “monsters”, in the second part of interview in which he discussed issues surrounding the pandemic. The musician, who ...
- How a nurse practitioner saved COVID-19 lives without vaccineson January 26, 2022 at 2:10 am
Vanessa Hamalian and her new Latitude Clinic have treated 1,092 COVID-19 patients with ivermectin and the FLCCC protocols, none with vaccines. Of those, 1,091 have recovered.
- Global Pediatric Vaccines Market Forecast 2022-2027, Featuring GlaxoSmithKline, Merck, Pfizer, Sanofi Pasteur and CSL - ResearchAndMarkets.comon January 26, 2022 at 2:01 am
Industry Trends, Growth, Size, Impact of COVID-19, Company Analysis" report has been added to ResearchAndMarkets.com's offering.
- Image of Japanese factory explosion misleadingly shared alongside claim it was 'storing vaccines'on January 26, 2022 at 1:07 am
An image of a damaged building has been shared repeatedly in Korean-language social media posts that claim it shows the aftermath of an explosion at "a factory storing Covid-19 vaccines" in Japan.
- New Studies Offer Reassurance On COVID Vaccines And Fertilityon January 25, 2022 at 8:23 pm
Recent research says getting vaccinated won't hurt your chance of getting pregnant — but getting COVID-19 might.
- The GOP’s anti-vaccine mandate push is seeping into other vaccines — and schoolson January 25, 2022 at 2:38 pm
The writing has been on the wall for a while. Now Republicans in some states are moving forward with actual proposals.
- RFK Jr. remarks on Anne Frank, vaccines draw condemnationon January 25, 2022 at 12:52 pm
Kennedy Jr. made “deeply offensive" comments when he suggested things are worse for people today than they were for Anne Frank, the teenager who died in a Nazi concentration camp after hiding with her ...
via Bing News