Scientists report that they have developed a novel compound that appears to protect mice against developing movement problems associated with Parkinson’s disease (PD).
The research, which could one day in the future translate into a therapy that could halt the progression of PD and thereby prevent the symptoms of the disease, appears in ACS’ Journal of Medicinal Chemistry.
Onyou Hwang, Ki Duk Park and colleagues explain that PD, which affects an estimated 4 million to 10 million people worldwide, is a progressive movement disorder with no known cure. It often starts with slight tremors and gets worse over time. Muscles go stiff. Walking becomes difficult. Speech is slurred. No one knows for certain what causes the disease, but research has shown that it’s linked with the loss of nerve cells in the brain that secrete dopamine, a chemical that is involved in movement and emotion. To find a potential new therapy for PD, the research team searched for a way to shield these brain cells.
They made 56 compounds and tested them to see which ones boosted the production of proteins that protect dopamine-releasing neurons from damage. Of those, one, which they call “12g,” proved to be the most active. Interestingly, it protected mice from developing PD-like symptoms in one laboratory test. “Taken together, 12g was found to effectively prevent the motor deficits that are associated with PD,” they say.
The Latest on: Parkinson’s disease
via Google News
The Latest on: Parkinson’s disease
- Fatty liver disease symptoms: Nail changes could signal the deadly condition - key signson March 3, 2021 at 12:20 am
FATTY liver disease is characterised by an accumulation of fat in the liver. Nail changes may signal you have an advanced form of the condition.
- Study investigates impact of exercise on Parkinson’s diseaseon March 2, 2021 at 9:20 pm
Researchers have found that activities like cycling may improve motor function and stamina in patients with Parkinson's disease.
- Sesaminol: Parkinson's disease's surprise medicineon March 2, 2021 at 9:04 pm
Researchers find that the chemical sesaminol, naturally occurring in sesame seeds, protects against Parkinson's disease by preventing neuronal damage that decreases the production of dopamine. In ...
- Thalamic morphology predicts the onset of freezing of gait in Parkinson’s diseaseon March 2, 2021 at 3:37 pm
The onset of freezing of gait (FOG) in Parkinson’s disease (PD) is a critical milestone, marked by a higher risk of falls and reduced quality of life. FOG is associated with alterations in subcortical ...
- Brain's Metabolic Run-up to Dementia Directly Linked to Hypertension, Carotid Diseaseon March 2, 2021 at 1:34 pm
Hypoperfusion by PET imaging in brain regions linked to cognitive function were independently related to preclinical carotid disease and CV risk score, particularly the hypertension component.
- Time to ditch the sausages? Eating meat or poultry just three times a week can increase your risk of heart disease, pneumonia and diabetes, study warnson March 2, 2021 at 10:02 am
The research from Oxford University found that a meat-lover who eats 70 grams of meat - processed or unprocessed - more than a peer is at 15 per cent higher risk of heart disease.
- Researchers find effective combination of therapies for managing mitochondrial diseaseon March 2, 2021 at 9:47 am
Researchers from the Mitochondrial Medicine Frontier Program at Children's Hospital of Philadelphia (CHOP) have demonstrated how one combination of therapies may be beneficial for patients with ...
- Parkinson's disease: Blood changes may occur years before diagnosison March 2, 2021 at 9:20 am
Although Parkinson's disease affects around 1%-2% of people over the age of 65, there is currently no cure. And by the time it is diagnosed—typically by identifying problems with movement, such as ...
- Yolanda Hadid on Her Battle with Lyme Disease: ‘Being in Remission Is an Everyday Blessing’on March 2, 2021 at 7:40 am
Yolanda Hadid is feeling grateful for her health. "I'm better than I've been in a long time," the former Real Housewives of Beverly Hills star, who was diagnosed with Lyme disease in 2012, tells ...
- Treating Parkinson’s Disease with Individualized Brain Cell Graftson March 2, 2021 at 5:00 am
Movement and depression symptoms associated with Parkinson's disease were relieved in monkeys's brain by grafted neurons.
via Bing News