Image shows the structure of the nanoparticle (left), and how the nanoparticles home in on a tumor and shrink it (right).
Researchers have developed a technique for creating nanoparticles that carry two different cancer-killing drugs into the body and deliver those drugs to separate parts of the cancer cell where they will be most effective.
The technique was developed by researchers at North Carolina State University and the University of North Carolina at Chapel Hill.
“In testing on laboratory mice, our technique resulted in significant improvement in breast cancer tumor reduction as compared to conventional treatment techniques,” says Dr. Zhen Gu, senior author of a paper on the research and an assistant professor in the joint biomedical engineering program at NC State and UNC-Chapel Hill.
“Cancer cells can develop resistance to chemotherapy drugs, but are less likely to develop resistance when multiple drugs are delivered simultaneously,” Gu says. “However, different drugs target different parts of the cancer cell. For example, the protein drug TRAIL is most effective against the cell membrane, while doxorubicin (Dox) is most effective when delivered to the nucleus. We’ve come up with a sequential and site-specific delivery technique that first delivers TRAIL to cancer cell membranes and then penetrates the membrane to deliver Dox to the nucleus.”
Gu’s research team developed nanoparticles with an outer shell made of hyaluronic acid (HA) woven together with TRAIL. The HA interacts with receptors on cancer cell membranes, which “grab” the nanoparticle. Enzymes in the cancer cell environment break down the HA, releasing TRAIL onto the cell membrane and ultimately triggering cell death.
When the HA shell breaks down, it also reveals the core of the nanoparticle, which is made of Dox that is embedded with peptides that allow the core to penetrate into the cancer cell. The cancer cell encases the core in a protective bubble called an endosome, but the peptides on the core cause the endosome to begin breaking apart. This spills the Dox into the cell where it can penetrate the nucleus and trigger cell death.
The Latest on: Nanoparticles for drug delivery
[google_news title=”” keyword=”Nanoparticles for drug delivery” num_posts=”10″ blurb_length=”0″ show_thumb=”left”]
via Google News
The Latest on: Nanoparticles for drug delivery
- pH-Sensitive Polymeric Nanoparticles for Tumor-Targeting Doxorubicin Delivery: Concept and Recent Advanceson September 24, 2023 at 5:00 pm
Doxorubicin is a potent chemotherapeutic drug applied in the clinics ... new advances in pH-sensitive polymeric nanoparticles for doxorubicin delivery are presented and discussed.
- Nanoparticles made from plant viruses could be farmers' new ally in pest controlon September 21, 2023 at 10:19 am
The work is detailed in a paper published in Nano Letters. Steinmetz's team drew inspiration from nanomedicine, where nanoparticles are being created for targeted drug delivery, and adapted this ...
- Nanoparticle Drug Delivery Systems Market Analysis Research Report [2023-2030] | 116 Pageson September 16, 2023 at 5:08 pm
360 Research Reports has published a new report titled as "Nanoparticle Drug Delivery Systems Market" by End User (Hospital, Retail Pharmacy, Other), Types (TYPE1), Region and Global Forecast to ...
- Liposomal and Lipid Nanoparticle Drug Delivery Systems Market Share Research Report [2023-2030] | 107 Pageson September 16, 2023 at 3:41 am
360 Research Reports has published a new report titled as "Liposomal and Lipid Nanoparticle Drug Delivery Systems Market" by End User (Hospital, Retail Pharmacy, Other), Types (TYPE1), Region and ...
- Renewable Solvent Suited for Drug-Delivery Systems and Medical Implantson September 6, 2023 at 5:00 pm
Biotech company Circa Group reports that a study using its renewable solvent Cyrene found that high-purity nanoparticles can be produced, opening up opportunities to use the material as a ...
- Renewable Solvent Suited for Drug-Delivery Systems and Medical Implantson September 6, 2023 at 5:00 pm
Biotech company Circa Group reports that a study using its renewable solvent Cyrene found that high-purity nanoparticles can be produced, opening up opportunities to use the material as a ...
- Using Nanoparticles in Targeted Drug Delivery and Photothermal Therapyon November 18, 2022 at 8:29 am
Discover the latest research and advances in nanoparticle technology. Nanoparticles are growing in popularity for drug delivery and photothermal therapy. A given nanoparticle can bear a specific ...
- Next Generation Lipid-Based Nanoparticles Delivery Summit | July 19-21, 2022on April 28, 2022 at 5:45 am
The recent success of the mRNA-LNP vaccines fueled biopharma to explore lipid-based nanoparticles for advanced drug delivery. The industry is now poised to exploit the full therapeutic potential ...
- Nanoform nanoparticle drug delivery delivers successful results for Herantis CDNF drug candidateon September 13, 2021 at 9:00 pm
study to further refine the size and shape of the nanoformed rhCDNF nanoparticles and evaluate biodistribution following intranasal delivery. “We are excited with these initial results that show ...
- Precision Nanomedicines for Targeted Drug Deliveryon August 19, 2020 at 9:16 am
Kidney-Targeted Therapeutics: We are synthesizing nanoparticles that specifically target the kidneys. These will facilitate the development of new medicines to address many types of kidney diseases.
via Bing News
