Our data suggest that we should be able to impact health span and life span quite strongly
Scientists at the Buck Institute for Research on Aging have promoted health and increased lifespan in Drosophila by altering the symbiotic, or commensal, relationship between bacteria and the absorptive cells lining the intestine. The research, appearing in the January 16, 2014 edition of Cell, provides a model for studying many of the dysfunctions that are characteristic of the aging gut and gives credence to the growing supposition that having the right balance of gut bacteria may be key to enjoying a long healthy life.
Even though recent research in humans has linked the composition of gut flora with diet and health in the elderly and the list of age-related diseases associated with changes in gut bacteria include cancer, diabetes, and inflammatory bowel disease, lead author and Buck faculty Heinrich Jasper, PhD, says there is no systematic understanding of how we go from having a young, healthy gut to one that is old and decrepit. “Our study explores age-related changes in the gut that include increased oxidative stress, inflammation, impaired efficiency of the immune response, and the over-proliferation of stem cells,” said Jasper. “It puts these changes into a hierarchical, causal relationship and highlights the points where we can intervene to rescue the negative results of microbial imbalance.”
Jasper says the bacterial load in fly intestines increases dramatically with age, resulting in an inflammatory condition. The imbalance is driven by chronic activation of the stress response gene FOXO (something that happens with age), which suppresses the activity of a class of molecules (PGRP-SCs, homologues of PGLYRPs in humans) that regulate the immune response to bacteria. PGRP-SC suppression deregulates signaling molecules (Rel/NFkB) that are important to mount an effective immune response to gut bacteria. The resulting immune imbalance allows bacterial numbers to expand, triggering an inflammatory response that includes the production of free radicals. Free radicals, in turn, cause over-proliferation of stem cells in the gut, resulting in epithelial dysplasia, a pre-cancerous state.
Jasper said the most exciting result of their study occurred when his group increased the expression of PGRP-SC in epithelial cells of the gut, which restored the microbial balance and limited stem cell proliferation. This enhancement of PGRP-SC function, which could be mimicked by drugs, was sufficient to increase lifespan of flies. “If we can understand how aging affects our commensal population – first in the fly and then in humans – – our data suggest that we should be able to impact health span and life span quite strongly, because it is the management of the commensal population that is critical to the health of the organism.”
The Latest on: Gut Bacteria
via Google News
The Latest on: Gut Bacteria
- Chemotherapy Disrupts Gut Bacteria in Cancer Patientson July 7, 2021 at 8:18 am
Researchers from Australia have found that the conventional chemotherapy used to treat various cancers disrupts the composition of microbiota in the gut. T | Cancer ...
- Food science researchers advance science behind gut health and prebioticson July 6, 2021 at 7:57 am
Bruce Hamaker, director of the Whistler Center for Carbohydrate Research and Distinguished Professor of Food Science, and Thaisa Moro Cantu-Jungles, his postdoctoral research associate, recently ...
- Could prebiotic snacks boost healthy gut bacteria in obesity?on July 6, 2021 at 3:55 am
A recent study suggests that snack food supplemented with particular types of fiber can transform the gut microbiota and influence health.
- Compelling new clues to how gut bacteria can influence social behavioron July 1, 2021 at 10:12 pm
An impressive new study has highlighted the gut-brain link between social behavior and gut microbes in mice. The thorough research shows how lacking certain gut bacteria can increase levels of a ...
- Identifying the neural link between gut bacteria and social behavior in miceon July 1, 2021 at 5:10 am
Could the germs that live inside of our bodies be affecting our ability to socialize and make friends? Research conducted in recent decades suggests that the answer—for mice—is yes.
- Gut bacteria may 'talk' to the brain, mouse study suggestson June 30, 2021 at 10:43 am
Mice carry a teeming community of bacteria in their guts, and these gut bugs influence how the rodents' brains work, according to a new study. Specifically, researchers wanted to find out how gut ...
- Industry group dismissive of artificial sweeteners’ effect on healthy gut bacteriaon June 28, 2021 at 8:45 am
Artificial sweeteners may turn healthy gut bacteria into harmful microbes that can damage the intestine and cause a number of infections including blood poisoning, according to UK scientists.
- 4 Mistakes That Could Hinder Your Gut Healthon June 27, 2021 at 2:02 pm
If you want to support good gut health, avoid these four common mistakes that can harm your good gut bacteria, according to an expert on the gut microbiome.
- Artificial sweeteners can turn healthy gut bacteria into pathogenson June 25, 2021 at 1:35 am
Sugar substitutes could cause harmful bacteria to invade the intestine, which can potentially lead to life-threatening infections.
- Sweeteners ‘can turn healthy gut bacteria into harmful microbes’on June 25, 2021 at 12:47 am
Authors say the changes caused to healthy gut bacteria by sweeteners could lead to ‘infection, sepsis and multiple-organ failure’ ...
via Bing News