Since insulin’s crucial discovery nearly a century ago, countless diabetes patients have had to inject themselves with the life-saving medicine.
Now scientists are reporting a new development toward a long-sought insulin pill that could save millions the pain of daily shots. Published in the ACS journal Biomacromolecules, the advance could someday not only eliminate the “ouch” factor, but also get needle-wary — and weary — patients to take their medicine when they should.
Sanyog Jain and colleagues explain that patients with diabetes sometimes skip doses or stop taking their insulin because the injections can be painful. But doing so puts their health in danger. An estimated 347 million people globally (about 26 million in the U.S.) are living with diabetes. In the U.S., more than a quarter of these patients are taking some kind of insulin therapy. For years, researchers have sought a way to transform delivery of this therapy from a shot to a pill, but it has been a challenge. The body’s digestive enzymes that are so good at breaking down food also break down insulin before it can get to work. In addition, insulin doesn’t get easily absorbed through the gut into the bloodstream. To overcome these hurdles, Jain’s team combined two approaches to shield insulin from the digestive enzymes and then get it into the blood.
They packaged insulin in tiny sacs made of lipids, or fats, called liposomes, which are already used in some treatments. Then, they wrapped the liposomes in layers of protective molecules called polyelectrolytes. To help these “layersomes” get absorbed into the bloodstream, they attached folic acid, a kind of vitamin B that has been shown to help transport liposomes across the intestinal wall into the blood. In rats, the delivery system lowered blood glucose levels almost as much as injected insulin, though the effects of the layersomes lasted longer than that of injected insulin.
The Latest on: Insulin pill
via Google News
The Latest on: Insulin pill
- Nanofibers for Medical and Cosmetics Market Size Forecast to Reach $4.2 Billion by 2026on April 12, 2021 at 3:05 pm
The Increasing Demand From Medical Industry Driving the Growth of Nanofibers for Medical and Cosmetics Market. The Nanofibers for Medical and Cosmetics Market size is forecast to reach $4.2 billion by ...
- Centrifugal multispun nanofibers put a new spin on COVID-19 maskson April 12, 2021 at 6:57 am
KAIST researchers have developed a novel nanofiber production technique called 'centrifugal multispinning' that will open the door for the safe and cost-effective mass production of high-performance ...
- Electrospinning Devices Market 2021 Industry Key Player, Trend and Segmented Data, Demand and Forecast by 2031on April 5, 2021 at 2:18 am
Apr 05, 2021 (WiredRelease via Comtex) -- Market.us has to return up with a brand new report specifically Global Electrospinning Devices Market standing and Outlook (2022-2031) that focuses on current ...
- IME Medical Electrospinning appoints Sander de Vos as Chief Business Officeron April 1, 2021 at 12:16 am
WAALRE, Netherlands, April 1, 2021 /PRNewswire/ -- IME Medical Electrospinning, a global leader in electrospun medical devices for tissue rebuilding and regenerative medicine as well as implants ...
- IME Medical Electrospinning appoints Sander de Vos as Chief Business Officeron April 1, 2021 at 12:09 am
Disclaimer | Commerce Policy | Made In NYC | Stock quotes by finanzen.net WAALRE, Netherlands, April 1, 2021 /PRNewswire/ -- IME Medical Electrospinning, a global leader in electrospun medical ...
via Bing News