Loyola University Medical Center is enrolling melanoma patients in the first clinical trial in the Midwest of an experimental vaccine that trains a patient’s immune system to fight the deadly cancer.
A batch of the immune system’s killer T cells are removed from the patient and genetically modified in a Loyola lab. Two genes are inserted into the T cells so that they will recognize tumor cells as abnormal.
The patient undergoes high-dose chemotherapy to kill most of his or her remaining T cells. This will make room for the genetically modified T cells when they are put back in the patient. The modified T cells, it is hoped, will recognize the tumor cells as abnormal and then attack and kill them.
“This clinical trial is a unique attempt to manipulate a person’s own immune system to attack their cancer in a more effective and specific manner,” said Joseph Clark, MD, one of the principal investigators of the trial.
The purpose of the Phase 1 trial is to determine the optimum dose and whether the treatment is safe. Four doses will be tested, with the highest dose consisting of about 5 billion genetically modified T cells. If Phase 1 demonstrates the treatment is safe, investigators will proceed to Phase 2, which will determine whether the treatment is effective.
Melanoma is the sixth-most-common cancer in Americans, and the most common fatal malignancy in young adults. Incidence is rising dramatically. About 1 in 50 people will be diagnosed with melanoma. In the 1960s, it was 1 in 600.
Surgery is highly successful if the cancer is caught early. But if the cancer has spread to other parts of the body, the five-year survival rate is only 15 to 20 percent, according to the American Cancer Society.
“This is a terrible, devastating disease,” Clark said. “It starts on the skin and can spread to just about anywhere in the body.” The clinical trial is open to patients with metastatic melanoma who are no longer responding to standard therapy. “We need better treatments,” Clark said. “Our clinical trial is designed for patients who have no other options.”
The Latest Google Headlines on:
The Latest Bing News on:
- Patients present with later stage melanoma during COVID-19 pandemicon May 13, 2022 at 9:05 am
Many melanoma patients presented with more advanced disease during the COVID-19 pandemic, according to a small study published in the Journal of the American Academy of Dermatology.Researchers ...
- Melanoma Prevalence, Mortality Mostly Stable Over the Past 30 Yearson May 13, 2022 at 5:08 am
Data from this new study suggest melanoma cases rose at a slower rate in lower-income countries, but the authors say that may be due to differences in case documentation.
- The Melanoma Research Alliance Names Dr. Marc Hurlbert as Chief Executive Officeron May 12, 2022 at 12:23 pm
A pharmacologist by training, Dr. Hurlbert is a visionary leader who brings more than 20 years of experience advancing medical research and public health. He has led medical and s ...
- Skin drug treatments may regress dangerous birthmarks and prevent melanomaon May 12, 2022 at 9:37 am
About one in 20,000 infants is born with what's called a congenital giant nevus—a huge, pigmented mole that may cover much of the face and body. Due to the mole's appearance and its risk of later ...
- School of Fish: What Fish Fins Are Teaching Scientists About Human Melanomaon May 12, 2022 at 12:13 am
Called acral melanoma, this type forms on the palms of the hand and soles of the feet and is typically very aggressive. It killed reggae singer Bob Marley. As a melanoma researcher, Dr. White was ...
- How to monitor your skin for melanoma and other skin canceron May 11, 2022 at 2:07 pm
May is Skin Cancer Awareness Month, and according to the CDC, skin cancer is the most common form of cancer in the United States. It is important to know your risks and how to monitor your skin ...
- Melanoma survivor Mark Zindler, son of iconic Houston newsman Marvin, says he’s a cautionary taleon May 11, 2022 at 9:00 am
Mark Zindler was never concerned about sunburns when he was younger. To the Houston native, they were just an unfortunate byproduct of an afternoon at the beach or on the golf course. Zindler, 68, ...
- DermTech Reinforces Longstanding Mission to Help Reduce Melanoma Deaths, Aligning with the Biden Administration's Renewed 'Cancer Moonshot' Programon May 10, 2022 at 2:11 pm
The renewed Cancer Moonshot program aligns with two of DermTech's core objectives: to improve access to high-quality dermatologic care and to use precision genomics to help eliminate deaths from ...
- UK indoor tanning ban would reduce melanoma deathson May 10, 2022 at 6:57 am
A ban of commercially available indoor tanning would substantially reduce deaths from melanoma, the most serious form of skin cancer, a study led by University of Manchester researchers has concluded.
- Medical Alert: Melanoma risk among adolescents and young adultson May 9, 2022 at 5:11 am
THANKS FOR JOINING US THIS MORNING. GOOD MORNING. MYLE PASURE. TALK ABOUT MELANOMA. I KNOW IT’S ONE OF THE MOST. COMMON FORMS OF CANCER WELL IT ACTUALLY IT’S ONE OFHE T RAREST SKIN CANCER. HOWEVER, IT ...
The Latest Google Headlines on:
The Latest Bing News on:
- T-Cell Behavior in Tumors Affects Immunotherapy Response, Predicts Patient Survivalon May 11, 2022 at 5:00 am
Study results overturn the prevailing model of immune responses in melanoma and point to different therapeutic approaches.
- Ultimovacs Announces Presentation of UV1 Immune Monitoring Data at Cancer Immunotherapy Annual Meetingon May 9, 2022 at 11:00 pm
Ultimovacs Announces Presentation of UV1 Immune Monitoring Data at Cancer Immunotherapy Annual Meeting | Regulatory News ...
- T cell behavior informs metastatic melanoma outcomeson May 9, 2022 at 11:21 am
Immunotherapy unleashes the power of the immune system to fight cancer. However, for some patients, immunotherapy doesn't work, and new research may help explain why.
- UK heatwave warning: ‘Common mistake’ people make that could increase skin cancer riskon May 7, 2022 at 2:41 am
THIS weekend the UK is set to enter a miniature heatwave. As temperatures rise inexorably to their highest point, thousands will feel the need to enter into prolonged periods in the sun. While ...
- Early detection of skin cancer saves lives, doctors sayon May 2, 2022 at 6:42 pm
Oregon State professor Arup Indra has spent more than a year working toward creating a vaccine to help prevent skin cancer. "Watch, watch, watch: prevention is much better than cure. But one of the ...
- Melanoma detection and diagnosis: How to spot the warning signson May 2, 2022 at 6:12 am
Kids 6 months to 5 years old could get COVID vaccine by June ...
- Takeda News - Drug Trial, Vaccineson April 29, 2022 at 5:41 pm
with Opdivo in the treatment of melanoma. Japan’s Eisai has significantly revised… French vaccines developer Valneva announced the successful completion of the Phase III pivotal trial of its ...
- What to know about immunotherapy for melanomaon April 27, 2022 at 5:00 pm
Immunotherapy is a type of biologic therapy that can treat certain diseases and cancers, including advanced melanoma, a type of skin cancer. Immunotherapy uses drugs to make the immune system more ...
- After COVID-19, mRNA vaccines could treat flu, HIV and even canceron April 25, 2022 at 6:49 am
numerous mRNA vaccine candidates are being researched and undergoing clinical trials for the treatment of cancer, including pancreatic cancer, colorectal cancer and melanoma, as well as HIV ...
- Blood test may accurately diagnose melanoma, study findson April 20, 2022 at 12:06 pm
Melanoma, or malignant melanoma ... Health News // 2 days ago Experimental COVID-19 vaccine pill shows promising results in early trials An experimental COVID-19 vaccine in pill form could ...