Other research shows treatment leads to high patient satisfaction
Swallowing pills containing a concentrate of fecal bacteria successfully stops recurrent bouts of debilitating Clostridium difficile (C. diff) infection by rebalancing the bacteria in the gut, suggests a study being presented at the IDWeek 2013™ meeting today.
Infection from C. diff bacteria is such a concern that the Centers for Disease Control and Prevention (CDC) named it one of the three most urgent threats in its recent landmark report on antibiotic resistance. C. diff sickens half a million Americans and kills 14,000 every year. C. diff infection can occur after people take antibiotics, wiping out the good bacteria in the gastrointestinal (GI) system, allowing C. diff to flourish and leading to severe diarrhea. In some patients, infection continues to recur despite standard treatment with antibiotics. For patients trapped in that cycle, doctors have transplanted feces from healthy donors into their GI system to rebalance the bacteria and stop infections from recurring.
Fecal transplantation typically is delivered by enema, colonoscopy (placing a tube in the colon) or nose tube and is effective in nine out of 10 patients, according to published reports. The IDWeek research suggests the less-invasive pills are a viable and effective delivery method.
“Recurrent C. diff infection is such a miserable experience and patients are so distraught that many ask for fecal transplantation because they’ve heard of its success,” said Thomas Louie, MD, professor of medicine at the University of Calgary, Alberta, and lead author of the pill study. “Many people might find the idea of fecal transplantation off-putting, but those with recurrent infection are thankful to have a treatment that works.”
Indeed, additional research being presented at the meeting showed patients who received fecal transplantation through a tube in the nose were highly satisfied with the treatment, and said they would likely recommend it to a friend.
Fecal Transplantation by Pill
University of Calgary researchers reported a 100 percent success rate – none of the 27 patients who took the tablet-sized pills had a recurrence of C. diff, even though all of them previously had had at least four bouts of the infection. Patients ingested between 24 and 34 capsules containing fecal bacteria, often donated by family members.
To make the pills, researchers processed the feces until it contained only bacteria, and then encapsulated the bacterial concentrate inside three layers of gelatin capsule. This ensured the pills wouldn’t leak or disintegrate until they were past the stomach and into the small intestine – a potential advantage over other methods because it covers more of the GI tract, does not involve invasive and more costly procedures, and is more comfortable for patients, Dr. Louie said.
Dr. Louie said he first made pills for fecal transplantation when one patient failed to respond to the enema method on two occasions and also could not tolerate a nasal tube for medical reasons. The pills are made individually.
“The pills are a one-shot deal and seem to work. They are easier for patients and are well-tolerated,” said Dr. Louie. “It’s an exciting development in the field and could possibly even be used to maintain the balance of bacteria in the GI system in patients at risk for C. diff.””
Patient Satisfaction of Fecal Transplantation
In the study of fecal transplantation tolerance, researchers surveyed 28 patients three months after they had undergone the treatment through a tube fed through the nose and GI system to the small intestine. On a scale of one to 10, average patient scores were: 9.6 for overall satisfaction; 9.9 for ease; and 9.9 for likelihood of recommending the procedure to a family member or friend.
“Patients with C. diff often have 20 or more stools a day, which seriously affects quality of life and so they are very open to this treatment,” said Ravi Kamepalli, MD, an infectious diseases physician at the Regional Infectious Disease-Infusion Center, Lima, Ohio, and lead author of the study. “Human beings are 90 percent bacteria and once that balance is altered with antibiotics, opportunistic infections can cause serious problems. All we are doing with this treatment is resetting the balance.”
The Latest Bing News on:
- Clostridium Diagnostics Market to reach US$ 7.8 Billion by 2032; Immunoassay-based Technology to Reign Supreme - Future Market Insights, Inc.on July 28, 2022 at 2:01 am
For instance, in March 2021, Peggy Lillis Foundation for Clostridium difficile infections announced a partnership with Ferring Pharmaceutical through a new sponsorship to assist new and existing ...
- Clostridium Diagnostics Market to reach US$ 7.8 Billion by 2032; Immunoassay-based Technology to Reign Supreme - Future Market Insights, Inc.on July 28, 2022 at 2:00 am
The global clostridium diagnostics market is projected to secure US$ 7.8 Billion by 2032 while recording a CAGR of 12.2% during the forecast period. The growth of the market can be attributed to the ...
- Refractory Clostridium difficile-associated Diarrheaon July 27, 2022 at 5:00 pm
Shilpa Grover, MD; Matthew J. Hamilton , MD; David L. Carr-Locke MD, FRCP, FACG, FASGE Series Editor: David L. Carr-Locke MD, FRCP, FACG, FASGE Shilpa Grover, MD ...
- Clostridium difficile infections market Size, Share, Industry Analysis, Regional Outlook, Trends, Future Scope and Forecasts to 2028on July 26, 2022 at 2:48 am
The trustworthy Clostridium difficile infections business report provides a profound overview of product specification, technology, product type and production analysis considering major ...
- Updates in the Management of Clostridium Difficile for Adultson July 25, 2022 at 5:00 pm
Clostridium difficile is a pathogen known to cause diarrhea and colitis. If not properly treated, it can recur as well as progress to life-threatening conditions such as toxic megacolon and ...
- Microbiome Changes in Patients With Burns Impact C. Difficile Incidenceon July 21, 2022 at 5:28 am
Diarrhea is very common among the critically ill, including patients with burns,” Parisa Shoaei, PhD, and Bahareh Vakili, PhD, note. “Following a burn injury, intestinal permeability, displacement of ...
- Clostridium Difficile News and Researchon July 14, 2022 at 5:01 pm
difficile (a nasty bacteria that can infect the bowel), which could lead to more targeted treatments for this and other similar diseases. Drinking beetroot juice promotes a mix of mouth bacteria ...
- Global Clostridium Difficile Diagnostic and Treatment Market To Record Rise In Incremental Opportunity During The Forecast Period 2022-2028on July 11, 2022 at 11:41 pm
Global Clostridium Difficile Diagnostic and Treatment Market was valued at USD 2,571.22 million in 2021 and it is expected to reach USD 5,663.87 million by 2028, with a CAGR of 11.9% during ...
- Clostridium difficileon July 8, 2022 at 3:34 am
Source: Focus Medica. Infection of the large intestine (colon) caused by the bacteria Clostridium difficile. Long-term use of antibiotics reduces the normal bacterial population in the intestine ...
- Addressing the Ongoing Risks of C. Diff in Healthcare Settingson July 5, 2022 at 5:00 pm
The bacterium Clostridioides difficile, which was formerly named Clostridium difficile and is now commonly known as C. difficile or simply C. diff, is a common microorganism found in the environment.
The Latest Google Headlines on:
The Latest Bing News on:
- Scientists Are Using Data From Olympic Athletes to Help Average Joes Get Healthieron July 31, 2022 at 12:00 pm
With the goal of sharing the genetic wonders—and matter—of top athletes with the rest of us, scientist are making cutting-edge advancements.
- Fecal Transplant in UC; Cancer Surveillance Lacking in Cirrhosis; Undiagnosed Celiacon July 28, 2022 at 11:04 am
Zaina Hamza, Staff Writer, MedPage Today July 28, 2022 Researchers believe they've identified two more reasons why fecal microbiota transplants from certain donors more often induce ulcerative colitis ...
- Researchers say freezing your fecal matter at a young age has future life-saving potentialon July 26, 2022 at 3:18 pm
In an article published in Trends in Molecular Medicine, Harvard scientists suggest preserving stool at a young age may prove to be life-saving in the future. The method is called autologous fecal ...
- Fecal Transplants See Success in 90 Percent of Bacterial Gut Infectionson July 25, 2022 at 5:00 pm
diff) infection, which causes severe diarrhea in sufferers. Fecal transplants are meant to take the microbiomes of healthy donors and allow them to flourish in the recipients, killing any C.
- Controversy intensifies over fecal transplantationon July 22, 2022 at 3:28 am
In addition, they stressed that further research is needed on the long-term effects of fecal transplants. They noted that regulating fecal transplants as a tissue is likely to facilitate improved ...
- Would You Take a Poop Pill?on July 18, 2022 at 5:00 pm
But even I cringed when I learned that researchers are now investigating fecal transplant pills. In other words, poop pills. Fecal microbiota transplant (FMT) research has shown a lot of promise for ...
- Building a poop bank for human fecal transplantson July 10, 2022 at 12:48 am
If something goes wrong, that often means relying on borrowing a microbiome jump start from a stranger by way of a fecal transplant. Not to put too fine a point on it, but that process involves ...
- Cambridge microbiome company looks beyond fecal transplantson July 6, 2022 at 3:52 pm
Three Boston firms are racing to develop pills based on a medical procedure called fecal microbiota transplant, in which feces from a healthy individual — teeming with good gut bacteria — are ...
- Lawyer of naturopath who produced fecal transplant material to treat autism claims he’s 'not bound by science'on July 4, 2022 at 7:23 am
Reports indicate the naturopath was using fecal microbiota transplantation, or fecal transplants, to treat symptoms of autism, constipation and other diagnoses at his clinic in Mexico. A lawyer for a ...