UMB 425 is being called a breakthrough in the development of therapeutics to treat chronic pain, acts on two different opioid receptors with diminished tolerance over time and no obvious toxic effects.
A team of researchers led by Andrew Coop, PhD, professor and chair of the Department of Pharmaceutical Sciences (PSC) at the University of Maryland School of Pharmacy (UMSOP), has developed a new opioid drug that shows great potential to advance treatment and improve quality of life for individuals living with chronic pain. Spotlighted in a recent issue of ACS Chemical Neuroscience, the compound, known as UMB 425, is as strong as morphine, but displays diminished tolerance over time with no obvious toxic effects.
“UMB 425 is a breakthrough in the development of therapeutics to treat chronic pain,” says Coop. “Unlike other drugs developed to act on only one biological target, UMB 425 acts on two different opioid receptors in the body. When activated at the same time, these receptors work together to provide pain relief and slow the body’s development of tolerance to the drug. This diminished tolerance allows a lower dose of the opioid to be administered for a longer time period, while still achieving the same level of pain relief.”
For individuals living with chronic pain, either as a result of injury or disease such as arthritis, opioids are the standard treatment. But as the dosage increases to offset the body’s tolerance to their effects, opioids cause a number of adverse effects, including constipation, nausea, drowsiness, and dizziness. The unique dual-profile of UMB 425 – made possible through Coop’s collaborations with Alexander MacKerell, PhD, professor in PSC and director of the School’s Computer Aided Drug Design Center, and Maureen Kane, PhD, assistant professor in PSC and co-director of the School’s Mass Spectrometry Facility – provides both pain relief as well as diminished tolerance in one drug.
“Historically, medicinal chemists have developed drugs aimed at only one biological target,” says Coop. “However, two drugs administered together have the potential to metabolize differently in different individuals, as well as affect patients’ adherence to both drugs. A single compound that is able to provide both pain relief and diminished tolerance has the advantage of a defined ratio that we can optimize to ensure patients receive the maximum pain relief, while experiencing minimum adverse effects.”
Coop and his team conducted several in vitro and in vivo studies to determine the drug’s effectiveness in alleviating pain and diminishing tolerance over time. If future research and clinical trials are successful, UMB 425 could have a significant impact on the treatment and quality of life for individuals living with chronic pain.
“The clinical implication of this research has the potential to be tremendous,” says Mary Lynn McPherson, PharmD, BCPS, CPE, professor and vice chair for academic affairs in the Department of Pharmacy Practice and Science, and an international authority in the fields of pain management and palliative care. “If clinicians can prescribe lower doses of opioids, they will not have to raise a patient’s dose because of tolerance to the analgesic effects. Using lower doses will result in less severe adverse effects for the patient, both short-term effects such as nausea and constipation, as well as long-term adverse effects on the endocrine and immunologic systems. This would be a highly significant advance in pain management.”
The Latest Bing News on:
- Physiotherapy Technique Significantly Improves Chronic Back Painon August 7, 2022 at 9:00 am
Sensorimotor retraining significantly improves pain intensity in chronic low back pain. The corresponding study was published in JAMA. "People w | Neuroscience ...
- MN law change, now in effect, could be life-saving for chronic pain patientson August 5, 2022 at 6:57 pm
On August 1, a change to a Minnesota state statute regarding opioid prescribing quietly ushered in a change that could be life-saving for people who suffer of severe, chronic pain. The change ...
- Smart Living: The chronic pain epidemic, rethinking how it’s treatedon August 4, 2022 at 3:35 pm
In fact, chronic pain is one of the most common reasons people see their doctor. Researchers estimate that the total value of lost productivity due to chronic pain is nearly 300 billion dollars a year ...
- Suffering from chronic pain? Here are 4 things to know about fibromyalgiaon August 4, 2022 at 2:16 am
Fibromyalgia imposes chronic widespread musculoskeletal pain. Sufferers describe it as a constant dull ache that persists over a prolonged period.
- The Strange Cure For The Chronic Foot Pain That Was Ruining My Lifeon August 3, 2022 at 9:30 pm
I’m not being dramatic when I say that chronic pain (which I later learned was plantar fasciitis) in my feet was ruining my life. I was waitressing at the time, and I spent a good part of the year ...
- What Happened When I Tested The Effects Of CBD Oil On Chronic Painon August 3, 2022 at 2:30 pm
So, I decided to do my own research because for one, I didn’t quite believe them, and two, because I suffer from chronic pain. If this magical CBD oil could help, I wanted to know everything I could.
- Mindfulness and sensory awareness training can help manage chronic painon August 3, 2022 at 12:37 pm
Nearly one in five Americans suffer from chronic pain. While medication is often prescribed to manage symptoms, there is increasing evidence that Mindfulness Based Stress Reduction can alleviate the ...
- Pain volume control: a link between chronic pain and opioid abuse in the brain - OSU, UM research suggestson August 3, 2022 at 11:45 am
Patients with fibromyalgia and those prone to opioid addiction may have something in common, researchers say: the part of the brain that controls the body’s perception of pain has the volume cranked ...
- Many living with chronic pain feel stigmatized by medical providerson August 3, 2022 at 9:50 am
The majority of people with chronic pain feel stigmatized by their medical providers. The finding is the result of a comprehensive survey report released today by the U.S. Pain Foundation. Among the ...
- An Effective New Treatment for Chronic Back Pain Targets the Nervous Systemon August 2, 2022 at 2:35 pm
A newly developed method called sensorimotor retraining appears to be effective at treating chronic back pain.
The Latest Google Headlines on:
The Latest Bing News on:
- Monolithic Power Systems (NASDAQ:MPWR) Given New $580.00 Price Target at KeyCorpon August 3, 2022 at 2:27 am
The company has a fifty day moving average of $420.67 and a 200 day moving average of $425.48. The firm has a market ... 25 shares during the last quarter. UMB Bank N A MO grew its stake in ...
- Calamos Advisors LLC Has $1.21 Million Holdings in National Grid plc (NYSE:NGG)on July 26, 2022 at 4:32 am
Calamos Advisors LLC lessened its stake in National Grid plc (NYSE:NGG – Get Rating) by 19.5% in the 1st quarter, according to the company in its most recent 13F filing with the Securities and ...
- DB Fitzpatrick & Co Inc Sells 1,053 Shares of Microsoft Co. (NASDAQ:MSFT)on July 22, 2022 at 5:04 am
UMB Bank N A MO grew its stake in Microsoft by ... Finally, Wells Fargo & Company reduced their price target on shares of Microsoft from $425.00 to $400.00 and set an “overweight” rating ...
- North Shore Airport, Umnak Island, United States [ UMB / ]on July 20, 2022 at 5:00 pm
Current time and date at North Shore Airport is 22:26:28 PM (AKDT) on Thursday, Jul 21, 2022 Looking for information on North Shore Airport, Umnak Island, United States? Know about North Shore Airport ...
- UMB Financial Corp.on July 14, 2022 at 5:01 pm
UMB Financial Corp. operates as a financial holding company, which engages in the provision of bank and asset services. It operates through the following segments: Commercial Banking ...
- Trains Between Sabarmati Bg and Ambala Cantonment • List of Sabarmati Bg - Ambala Cantonment Trainson April 24, 2022 at 1:07 am
Find all trains running between Ambala Cantonment (UMB) and Sabarmati Bg (SBIB). This page gives train name, train number and timing of trains operating on the Ambala Cantonment - Sabarmati Bg route.