English: Aedes aegypti in Dar es Salaam, Tanzania (Photo credit: Wikipedia)
Indian scientists have achieved an important breakthrough in their efforts to develop a vaccine to prevent the deadly dengue.
Supported by the Department of Biotechnology under the Ministry of Science & Technology, scientists at International Centre for Genetic Engineering and Biotechnology (ICGEB) in New Delhi have developed a non-infectious dengue vaccine from yeast.
Preliminary animal trials of the vaccine have yielded good results.
“Search for a dengue vaccine has been going on across the world for past several decades. We, at our centre, started experiments seven years ago. The new technology we have used, i.e. recombinant DNA technology, to develop the dengue vaccine is a breakthrough,” said Dr Navin Khanna, group leader of Recombinant Gene Products Group, ICGEB.
The initial trials done on mice gave encouraging signs. The research team explored virus-like particles which can provide “robust immunity” against the vector-borne disease that is endemic to more than a hundred countries.
“There are four closely related dengue viruses (DENVs) that cause this disease. A vaccine that can protect against all four DENVs is an un-met public health need,” said Dr Khanna.
Explaining the need to explore a new technology to develop the vaccine, he said: “Efforts to develop a live attenuated vaccine (a vaccine created by reducing the virulence of a pathogen but still keeping it viable) have encountered unexpected interactions between the vaccine viruses, raising safety concerns. This underscored the need to experiment with non-replicating vaccine options.”
Among the disadvantages of the vaccine developed by live attenuated technology is that it can cause severe complications in patients with low immunity. The ICGEB scientists used the yeast ‘Pichia pastoris’ to develop dengue virus-like particles.
“Using recombinant DNA technology, we have created non-infectious dengue virus-like particles made of only the major DENV ‘envelope protein’ important for eliciting virus-specific immunity. These virus-like particles elicit high levels of virus-neutralising antibodies which protected the mice significantly against lethal DENV challenge,” said Dr Khanna.
The Latest Bing News on:
Dengue vaccine
- Singapore records 19 dengue deaths in 2022, nearly four times 2021’s tollon January 31, 2023 at 8:47 pm
SINGAPORE - There were 19 deaths from dengue in Singapore in 2022, with four of them reported in the last quarter of the year, according to figures from the National Environment Agency (NEA). This is ...
- WHO urges investment in neglected tropical diseaseson January 30, 2023 at 5:12 am
The World Health Organization on Monday called for greater investment in combating neglected tropical diseases, which left more than 1.6 billion people, often in least-developed countries, ...
- Countries which chose Covishield fared better than those that took mRNA vax: Adar Poonawallaon January 29, 2023 at 10:04 pm
Countries which have taken Covishield have fared much better than those which relied only on mRNA vaccines, Serum Institute of India, chief executive - Kenya breaking news | Kenya news today | ...
- From 51 in Dec to 26 in Jan, dengue cases dip in Maduraion January 29, 2023 at 6:31 pm
MADURAI: Despite a spike in dengue cases in December 2022, with 51 cases recorded, officials have reported a decline in cases in January. As of January 28, as many as 26 dengue cases have been ...
- Hemorrhagic Fever Vaccine Market : Research Report Analysis by Competitors, Sales, Revenue and Industry Size 2023 To 2029on January 29, 2023 at 4:18 pm
Hemorrhagic Fever Vaccine Market Size is projected to Reach Multimillion USD by 2029, In comparison to 2022, at ...
- Will roll out HPV vaccine Cervavac through govt programs: Adar Poonawalaon January 25, 2023 at 2:03 am
Serum Institute of India launched the first made-in-India HPV vaccine Cervavac. SII CEO Adar Poonawala said that the HPV vaccine will be slowly rolled out across the country through govt programmes.
- 14 more hospitalised with dengueon January 24, 2023 at 4:00 pm
At least 14 dengue patients were hospitalised across the country in the last 24 hours till yesterday morning. Of them, nine are from outside Dhaka, according to the DGHS. For all latest news ...
- Dengue Vaccine Market Research | Edition 2023 | Recent Developments And SWOT Analysis 2028on January 23, 2023 at 12:45 am
Major Players operating in the dengue vaccine market include Sanofi Pasteur, Biological E. Limited, Merck & Co., Inc. Takeda Pharmaceutical Company Ltd. DOUGLAS, ISLE OF MAN, January 23 ...
- Bacteria-infected mosquitoes against dengueon January 20, 2023 at 6:15 am
According to government estimates, about 86,000 people could avoid getting infected with dengue. People are urged to continue protecting themselves from mosquito bites, but avoid destroying the ...
- Indonesian Minister Explores Investment plan with Takeda for Dengue Fever Vaccineon January 20, 2023 at 5:32 am
Investment Minister and Investment Coordinating Board Head Bahlil Lahadalia is exploring investment plans with a Japanese pharmaceutical company.
The Latest Google Headlines on:
Dengue vaccine
[google_news title=”” keyword=”Dengue vaccine” num_posts=”10″ blurb_length=”0″ show_thumb=”left”]
The Latest Bing News on:
Dengue fever
- Health office sounds alarm as dengue cases spiral in Iloilo Cityon February 1, 2023 at 4:36 am
The City Health Office (CHO) has called on the public to intensify the implementation of the "4S" strategy as a preventive measure amid the increasing number of dengue fever cases here.Assistant City ...
- Siliguri concerned over rising Dengue cases in winterson January 31, 2023 at 4:54 pm
Three dengue cases were reported in the Siliguri Municipal Corporation (SMC) area this month, raising concerns over such cases in the winters. Many residents said mosquito bites had increased sharply ...
- Kantha Bopha outpatient visits jump 71% in 2022on January 31, 2023 at 7:13 am
Last year, nearly 660,000 sick children were treated in the outpatient ward of Kantha Bopha Children’s Hospital – a 71 per cent increase on 2021 figures, according to a hospital report. “659,608 sick ...
- DOH-8 cites surge in dengue cases in first 3 weeks of Januaryon January 30, 2023 at 9:05 pm
A dengue-carrying mosquito PNA file photo TACLOBAN CITY -The Department of Health DOH in Eastern Visayas has reported higher dengue fever cases in the first three weeks of 2023 and warned that ...
- QC officials report hike in dengue caseson January 30, 2023 at 8:01 am
The number of dengue cases in Quezon City has increased by 350% from January 1 to 21 compared to the same period last year, according to a report on Super Radyo DZBB.
- From 51 in Dec to 26 in Jan, dengue cases dip in Maduraion January 29, 2023 at 5:52 pm
MADURAI: Despite a spike in dengue cases in December 2022, with 51 cases recorded, officials have reported a decline in cases in January.
- Boy from Arakkonam dies of dengue at Rajiv Gandhi Government General Hospital in Chennaion January 29, 2023 at 6:20 am
Three more persons hospitalised with the fever in Ranipet; the Public Health Department has intensified the anti-mosquito drive in the district ...
- Rising problems as Laos logs 238 dengue cases already this yearon January 27, 2023 at 9:48 pm
Laos has so far registered 238 dengue cases in 2023, according to figures from the Lao Ministry of Health. According to a report issued Friday by the Centre of Information and Education for Health ...
- Villagers asked to focus on dengue prevention at gram sabha meetingon January 26, 2023 at 5:56 am
Residents of Veppampatti village in Theni district were asked to focus on dengue prevention exercise by keeping their surroundings clean and dry, said Collector K.V. Muralidharan here on Thursday. As ...
- Dengue fever: 14 hospitalised in 24 hourson January 24, 2023 at 9:10 am
The total number of deaths from dengue fever was 281 last year while the total number of cases was 62,382, according to the DGHS.
The Latest Google Headlines on:
Dengue fever
[google_news title=”” keyword=”Dengue fever” num_posts=”10″ blurb_length=”0″ show_thumb=”left”]
