My left eye retina (Photo credit: Richard Masoner / Cyclelicious)
Researchers from the Centre for Genomic Regulation (CRG) in Barcelona have managed to regenerate the retina thanks to neuronal reprogramming.
There are currently several lines of research that explore the possibility of tissue regeneration through cell reprogramming. One of the mechanisms being studied is reprogramming through cell fusion.
The researcher Pia Cosma and her team have used the cell fusion mechanism to reprogramme the neurones in the retina. This mechanism consists of introducing bone marrow stem cells into the damaged retina. The new undifferentiated cells fuse with the retinal neurones and these acquire the ability to regenerate the tissue.
For the first time we have managed to regenerate the retina and reprogramme its neurones through in vivo cell fusion. We have identified a signalling pathway that, once activated, allows the neurones to be reprogrammed through their fusion with bone marrow cells”, explains Pia Cosma, head of the Reprogramming and Regeneration group at the Centre for Genomic Regulation and ICREA research professor. “This discovery is important not only because of the possible medical applications for retinal regeneration but also for the possible regeneration of other nervous tissues”, says Daniela Sanges, first author of the work and postdoctoral researcher in Pia Cosma’s laboratory.
The study, published by the prestigious journal Cell Reports, demonstrates that the regeneration of nervous tissue by means of cell fusion is possible in mammals and describes this new technique as a potential mechanism for the regeneration of more complex nervous tissue.
The Latest Bing News on:
Retina regeneration
- Deciphering Proteins and their Functions in the Regenerating Retinaon July 29, 2022 at 5:00 pm
Neurons of the mammalian CNS, including retinal ganglion cells, lack, in contrast to the PNS, the ability to regenerate axons spontaneously after injury. Regeneration of the CNS is extremely ...
- New Study Reveals How Zebrafish Can Restore Damaged Hearton July 26, 2022 at 4:07 am
New research demonstrates how zebrafish can regenerate heart tissue after injury.The cardiomyocytes are harmed when they are oxygen-deprived during a heart attack, and chronic scarring takes ...
- Zebrafish Can Repair a Damaged Heart, And a New Study Reveals Howon July 26, 2022 at 12:40 am
Zebrafish are marvelous creatures. Not only are they completely see-through, but they can also grow new organs. We already knew these translucent little fish could regenerate retinal tissue in their e ...
- Seeking Enlightenment: The Quest To Restore Vision In Humanson July 22, 2022 at 5:00 pm
More recently, the possibility of restoring functionality of a damaged retina and optic nerve by having the tissue regrow itself have been examined as well. OSK-induced axon regeneration ...
- Autologous Induced Stem-Cell–Derived Retinal Cells for Macular Degenerationon July 20, 2022 at 5:00 pm
We assessed the feasibility of transplanting a sheet of retinal pigment epithelial (RPE) cells differentiated from induced pluripotent stem cells (iPSCs) in a patient with neovascular age-related ...
- Deciphering Proteins and their Functions in the Regenerating Retinaon July 14, 2022 at 5:01 pm
Neurons of the mammalian CNS, including retinal ganglion cells, lack, in contrast to the PNS, the ability to regenerate axons spontaneously after injury. Regeneration of the CNS is extremely ...
- Endogena Therapeutics transitions into clinical stage with its novel regenerative treatment for blindness caused by retinitis pigmentosaon July 12, 2022 at 3:30 am
a photoreceptor regeneration treatment for retinitis pigmentosa (RP). RP is a group of inherited diseases causing slow and progressive retinal degeneration and loss of vision, for which there is ...
- Endogena Therapeutics transitions into clinical stage with its novel regenerative treatment for blindness caused by retinitis pigmentosaon July 12, 2022 at 12:18 am
a photoreceptor regeneration treatment for retinitis pigmentosa (RP). RP is a group of inherited diseases causing slow and progressive retinal degeneration and loss of vision, for which there is ...
The Latest Google Headlines on:
Retina regeneration
The Latest Bing News on:
Neuronal reprogramming
- Global Stem Cell Market to Reach at US$ 25.68 billion by 2028on July 28, 2022 at 1:30 am
The growing emphasis on the treatment of neurological illnesses adds to ... a little amount of a patient’s blood or skin cells and reprogramming them to make new cells and tissue for transplant.
- Reverse-Engineering Brains, One Neuron At A Timeon July 26, 2022 at 5:00 pm
And a final note of trivia: with better understanding of neurons, [Dr. Shubert] says we now know real neural networks to be quite different from the software creations they inspired, spurring ...
- ALS: Early disease mechanisms discoveredon July 19, 2022 at 5:57 am
Turning back the biological clock by reprogramming cells into stem cells Beate Winner is a professor for stem cell models for rare neural diseases at FAU, head of the Department of Stem Cell ...
- Researchers See the Formation of Motor Memories in Miceon July 18, 2022 at 11:33 am
These patterns may involve neural networks of hundreds or even thousands of cells ... With two-photon microscopy, the researchers saw neurons reprogram themselves while mice learned. In the motor ...
- Enrichment of the Embryonic Stem Cell Reprogramming Factors Oct4, Nanog, Myc, and Sox2 in Benign and Malignant Vascular Tumorson July 15, 2022 at 5:00 pm
[6–9] It was recently reported that benign infantile hemangiomas, which are the most common tumors of infancy, express higher levels of neural crest ... of the stem cell reprogramming factors ...
- Mogrify and Astellas announce collaboration to conduct research on in vivo regenerative medicine approaches to address sensorineural hearing losson July 5, 2022 at 1:38 am
Disley, Ph.D., "Mogrify ® "), a biopharmaceutical company transforming the lives of patients through a novel class of in vivo reprogramming therapies, and Astellas Pharma Inc. (TSE: 4503 ...
