My left eye retina (Photo credit: Richard Masoner / Cyclelicious)
Researchers from the Centre for Genomic Regulation (CRG) in Barcelona have managed to regenerate the retina thanks to neuronal reprogramming.
There are currently several lines of research that explore the possibility of tissue regeneration through cell reprogramming. One of the mechanisms being studied is reprogramming through cell fusion.
The researcher Pia Cosma and her team have used the cell fusion mechanism to reprogramme the neurones in the retina. This mechanism consists of introducing bone marrow stem cells into the damaged retina. The new undifferentiated cells fuse with the retinal neurones and these acquire the ability to regenerate the tissue.
For the first time we have managed to regenerate the retina and reprogramme its neurones through in vivo cell fusion. We have identified a signalling pathway that, once activated, allows the neurones to be reprogrammed through their fusion with bone marrow cells”, explains Pia Cosma, head of the Reprogramming and Regeneration group at the Centre for Genomic Regulation and ICREA research professor. “This discovery is important not only because of the possible medical applications for retinal regeneration but also for the possible regeneration of other nervous tissues”, says Daniela Sanges, first author of the work and postdoctoral researcher in Pia Cosma’s laboratory.
The study, published by the prestigious journal Cell Reports, demonstrates that the regeneration of nervous tissue by means of cell fusion is possible in mammals and describes this new technique as a potential mechanism for the regeneration of more complex nervous tissue.
The Latest Bing News on:
Retina regeneration
- Retina 'hardwired' to predict path of moving objectson August 2, 2021 at 10:30 am
Neural circuits in the primate retina can generate the information needed to predict the path of a moving object before visual signals even leave the eye, UW Medicine researchers demonstrate in a ...
- Researchers Find Regenerating the Inner Ear May Be Possibleon August 2, 2021 at 7:43 am
“Adult mammalian tissues such as heart, brain, retina, and the sensory structures of the inner ear do not effectively regenerate, although a latent capacity for regeneration exists at embryonic ...
- Latent Regenerative Potential of the Inner Ear Exploredon August 2, 2021 at 1:28 am
Scientists have identified a natural barrier to the regeneration of the inner ear’s sensory cells, which are lost in hearing and balance disorders. Overcoming this barrier may be a first step in ...
- Latent Regenerative Potential of the Inner Ear Exploredon August 2, 2021 at 12:56 am
Scientists from the USC Stem Cell laboratory of Neil Segil have identified a natural barrier to the regeneration of the inner ear’s sensory cells, which are lost in hearing and balance disorders.
- University of Southern California: USC Stem Cell scientists explore the latent regenerative potential of the inner earon July 31, 2021 at 4:58 am
Scientists from the USC Stem Cell laboratory of Neil Segil have identified a natural barrier to the regeneration of the inner ear’s sensory cells, which are lost in hearing and balance disorders. Over ...
- Stem Cell Scientists Explore the Latent Regenerative Potential of the Inner Earon July 31, 2021 at 12:52 am
Scientists from the USC Stem Cell laboratory of Neil Segil have identified a natural barrier to the regeneration of the inner ear’s sensory cells, which are lost in hearing and balance disorders. Over ...
- USC Stem Cell scientists explore the latent regenerative potential of the inner earon July 30, 2021 at 8:04 am
Scientists from the USC Stem Cell laboratory of Neil Segil have identified a natural barrier to the regeneration of the ... such as the retina, kidney, lung, and heart.” Additional co-authors ...
- USC Stem Cell scientists explore latent regenerative potential of inner earon July 30, 2021 at 7:02 am
Scientists from the USC Stem Cell laboratory of Neil Segil have identified a natural barrier to the regeneration of the inner ear's sensory cells, ...
- Scientists explore the latent regenerative potential of the inner earon July 29, 2021 at 5:00 pm
Scientists have identified a natural barrier to the regeneration of the inner ... useful in other non-regenerating tissues, such as the retina, kidney, lung, and heart." Keck School of Medicine ...
- Scientists explore the latent regenerative potential of the inner earon July 29, 2021 at 5:00 pm
Scientists from the USC Stem Cell laboratory of Neil Segil have identified a natural barrier to the regeneration of the ... such as the retina, kidney, lung, and heart." ...
The Latest Google Headlines on:
Retina regeneration
The Latest Bing News on:
Neuronal reprogramming
- The Shambala Secret Audio Reviews: SHOCKING Customer Report!on August 3, 2021 at 2:17 am
The Shambala Secret is the excellent manifestation program created based on the concept of reprogramming the subconscious conductor found inside you. It helps you transform your life by focusing on ...
- Can Cells Rewind The Wrinkles Of Time?on July 31, 2021 at 5:00 pm
researchers explore whether reversing that methylation can reprogram the cells back to a more youthful state. They used modified adenoviruses to introduce three specific transcription factors into ...
- Nuclear accumulation of CHMP7 initiates nuclear pore complex injury and subsequent TDP-43 dysfunction in sporadic and familial ALSon July 30, 2021 at 2:02 am
However, the reprogramming of patient-derived fibroblasts and peripheral blood mononuclear cells (PBMCs) into induced pluripotent stem cells (iPSCs) allows for the controlled differentiation into ...
- New Psychedelic Therapy AKO004 Under Development by Akomeon July 29, 2021 at 10:00 pm
A new psychedelic drug formulation called AKO004 is now under development by Akome Biotech, a wholly owned subsidiary of Core One Labs, as a potential treatment for Parkinson’s disease. The company ...
- Reprogrammed whale neurons predict neurotoxicity of environmental pollutantson July 26, 2021 at 5:00 pm
A research team has directly reprogrammed whale somatic cells to neuronal cells ... Japan succeeded in direct reprogramming the fibroblasts of stranded melon-headed whales (Peponocephala electra ...
- A Root in Synapsis and the Other One in the Gut Microbiome-Brain Axis: Are the Two Poles of Ketogenic Diet Enough to Challenge Glioblastoma?on July 23, 2021 at 9:31 am
Glioblastoma is the most frequent and aggressive brain cancer in adults. While precision medicine in oncology has produced remarkable progress in several malignancies, treatment of glioblastoma has ...
- Reprogramming Stem Cells Could Soon Lead Us to a World Without Paralysison July 21, 2021 at 5:01 pm
The researchers are hopeful that their study can help build on other research in cell reprogramming. “Our study not only informs the study of motor neuron development and its associated ...
- Signaling molecule may help prevent Alzheimer's diseaseon July 21, 2021 at 12:45 am
"Neuron death can be caused by improper immune ... Signaling molecule may help prevent Alzheimer's disease: Interleukin-3 may reprogram immune responses in the brain that cause cell death and ...
- Overview of Recent Advances in the Generation of Human Neurons and Neural Stem Cells Through Reprogramming and Differentiation Techniqueson July 10, 2021 at 5:00 pm
Recent advances have been achieved in techniques for reprogramming somatic cells directly to neurons and neural stem cells, and in differentiating pluripotent cells to neurons and neural stem cells.
