An international group of scientists has shown that a drug candidate designed by scientists from the Florida campus of The Scripps Research Institute (TSRI) significantly increases exercise endurance in animal models.
These findings could lead to new approaches to helping people with conditions that acutely limit exercise tolerance, such as obesity, chronic obstructive pulmonary disease (COPD) and congestive heart failure, as well as the decline of muscle capacity associated with aging.
The study was published July 14, 2013, by the journal Nature Medicine.
The drug candidate, SR9009, is one of a pair of compounds developed in the laboratory of TSRI Professor Thomas Burris and described in a March 2012 issue of the journal Nature as reducing obesity in animal models. The compounds affect the core biological clock, which synchronizes the rhythm of the body’s activity with the 24-hour cycle of day and night.
The compounds work by binding to one of the body’s natural molecules called Rev-erb?, which influences lipid and glucose metabolism in the liver, the production of fat-storing cells and the response of macrophages (cells that remove dying or dead cells) during inflammation.
In the new study, a team led by scientists at the Institut Pasteur de Lille in France demonstrated that mice lacking Rev-erb? had decreased skeletal muscle metabolic activity and running capacity. Burris’ group showed that activation of Rev-erb? with SR9009 led to increased metabolic activity in skeletal muscle in both culture and in mice. The treated mice had a 50 percent increase in running capacity, measured by both time and distance.
“The animals actually get muscles like an athlete who has been training,” said Burris. “The pattern of gene expression after treatment with SR9009 is that of an oxidative-type muscle— again, just like an athlete.”
The authors of the new study suggest that Rev-erb? affects muscle cells by promoting both the creation of new mitochondria (often referred to as the “power plants” of the cell) and the clearance of those mitochondria that are defective.
The Latest Bing News on:
Increases exercise endurance
- In Your Prime: Looking for increased exercise? Try trail running at area parkson September 3, 2021 at 11:56 am
Trail running is thousands of years too old to be considered a new activity, but the COVID-19 pandemic, especially during periods of stay-at-home orders, has given communities a new appreciation for ...
- 11 Fitness Studios (HIIT, Pilates, Spin) for Every Budget With Free or Discounted First-Timer Trialson September 2, 2021 at 5:00 pm
Shake up your routine with these free or affordable workouts. We used to feel lazy about working out once in a while, but prolonged working from home is detrimental to our waistline – especially with ...
- Are exercise bike good for weight loss? (Yes, here's why)on September 1, 2021 at 3:00 pm
Exercise bikes are an excellent system to get in shape, but the question is, 'Are they good for weight loss?' We know freehand or aerobic exercise is important for burning fat and losing weight. But ...
- How often should you really exercise?on September 1, 2021 at 12:10 am
How often you should train depends on a lot of different factors — such as your training goals, the intensity of your exercise and any history of injury you may have. The type of training you do can ...
- Exercise Causes Oxidative Stress. Here's What It Means for Your Healthon August 31, 2021 at 8:29 am
Oxidative stress is too-high levels of free radicals in the body, and can cause disease. But exercise-induced oxidative stress can be good for you. Here's how.
- How often should you exercise to get in shape?on August 31, 2021 at 5:00 am
Elite athletes train almost ten to 14 times per week, clocking up numerous hours on the track and in the gym. But for the rest of us, getting into shape does not necessarily mean such an arduous ...
- Why Endurance Athletes Should Consider Single-Leg Trainingon August 28, 2021 at 2:00 am
Proponents of the former argue that, by training one limb at a time, you generate more force overall and presumably get better adaptations as a result. Those who favor the latter counter that bigger ...
- Fitness goals, intensity of workout and many other factors determine how often you should exercise to get in shapeon August 26, 2021 at 8:37 pm
But for the rest of us, getting into shape does not necessarily mean such an arduous regime. How often you should train depends on a lot of different factors - such as your training goals, the ...
- How to keep improving your cycling as you ageon August 26, 2021 at 9:51 am
How can we age and still get faster? After all, the oldest athletes tend to be the most experienced. According to strength and endurance records, men and women reach their peak performances between ...
- Fatty Acid Profiles of Serum Lipid Fractions Change Minimally in Sled Dogs Before and After Short Bouts of Exerciseon August 26, 2021 at 8:08 am
Although emerging data suggests a greater influence of gluconeogenic precursors, endurance sled dogs have long appeared to rely heavily on fatty acid oxidation for sustained energy production. However ...
The Latest Google Headlines on:
Increases exercise endurance
The Latest Bing News on:
- SLU Researchers Study a New Way to Lower LDL Cholesterolon March 3, 2017 at 9:10 am
Similarly, in a previous study, Burris found that a synthetic version of REV-ERB called SR9009 reduces total plasma cholesterol and triglyceride levels in an animal model. In this study, Burris found ...