The antibiotic planosporicin is produced by the soil bacterium Planomonospora alba
An antibiotic has been found to stimulate its own production.
The findings, to be published in PNAS, could make it easier to scale up antibiotic production for commercialisation.
Scientists Dr Emma Sherwood and Professor Mervyn Bibb from the John Innes Centre were able to use their discovery of how the antibiotic is naturally produced to markedly increase the level of production.
“We have shown for the first time that an antibiotic with clinical potential can act as signalling molecule to trigger its own synthesis,” said Professor Bibb.
The antibiotic called planosporicin is produced by a soil bacterium called Planomonospora alba. When nutrients become limited, a small amount of the antibiotic is produced. The antibiotic is then able to trigger a mechanism which coordinates its own production throughout the bacterial population resulting in high levels.
“A frequent stumbling block in developing a natural product for commercialisation is being able to provide enough material for clinical trials,” said Professor Bibb.
“Our work shows with the right understanding it is possible to increase productivity very dramatically in a targeted and knowledge-based manner.”
The Latest Bing News on:
Antibiotic production
- Aurobindo, Kinvan, K'taka Antibiotics first to get PLI for drugson January 22, 2021 at 8:53 am
While Aurobindo Pharma has committed an investment of Rs 3,039 crore to set up production facilities for three eligible products, Kinvan will invest Rs 447.17 crore to build 300 MT capacity plant to p ...
- Overuse of antibiotics for meat production drives resistance in humanson January 20, 2021 at 8:05 pm
Mention antibiotic resistance and few people would link what is increasingly being recognised as a growing global health crisis with a Big Mac. But in the US, animals farmed for food account for most ...
- Irish soil can offer more hope in fight against antibiotic resistance, researchers showon January 20, 2021 at 4:00 pm
Scientists who highlighted the bug-busting properties of bacteria in Northern Irish soil have made another exciting discovery in the quest to discover new antibiotics.
- Origins of Antibiotic Resistanceon January 20, 2021 at 8:09 am
As the use of antibiotics increases, as does antibiotic resistance. It is vital to understand how antibiotic resistance has emerged and the ways to prevent it.
- Synthesis of potent antibiotic follows unusual chemical pathwayon January 18, 2021 at 10:08 am
Images of a protein involved in creating a potent antibiotic reveal the unusual first steps of the antibiotic's synthesis. The improved understanding of the chemistry behind this process could allow ...
- Researchers show Irish soil can offer more hope in fight against antibiotic resistanceon January 17, 2021 at 2:24 am
Scientists who highlighted the bug-busting properties of bacteria in Northern Irish soil have made another exciting discovery in the quest to discover new antibiotics. The Traditional Medicine ...
- Antibiotics Market 2021 Share Growing Rapidly with Recent Trends, Development, Revenue, Demand and Forecast to 2026 | Says MarketReportsWorld.comon January 15, 2021 at 5:11 am
Global “Antibiotics Market” report studies the market in-depth and provides an all-encompassing analysis of the key ...
- Scientists make new discovery in the quest for novel antibioticson January 14, 2021 at 9:48 pm
Scientists who highlighted the bug-busting properties of bacteria in Northern Irish soil have made another exciting discovery in the quest to discover new antibiotics.
- Phage viruses can make superbugs susceptible to antibiotics againon January 12, 2021 at 9:22 pm
Viruses firmly hold the world’s attention at the moment, but we shouldn’t ignore the rising health threat that bacteria pose, too. The crafty critters are fast evolving resistance to antibiotics, ...
- Gene-Editing Enhances Superbug-Slaying Antibioticson January 12, 2021 at 4:00 pm
Scientists have used gene-editing advances to achieve a tenfold increase in the production of super-bug targeting formicamycin antibiotics.
The Latest Google Headlines on:
Antibiotic production
The Latest Bing News on:
Antibiotic has been found to stimulate its own production
- Is garlic nature's best medicine?on January 19, 2021 at 4:00 pm
For hundreds of years, garlic has been renowned for its usefulness in treating a whole range of ailments, from impotence to stomach bugs. But recent studies have found that garlic has more serious ...
- In the best of corporate health: Dilip Suranaon January 19, 2021 at 3:40 am
Under the leadership of Chairman and Managing Director Dilip Surana, Micro Labs is showing no signs of slowing down in its quest to become one of the world’s leading generic pharmaceutical companies.
- The Lab-Leak Hypothesison January 4, 2021 at 3:38 pm
This article was featured in One Great Story, New York’s reading recommendation newsletter. Sign up here to get it nightly. What happened was fairly simple, I’ve come to believe. It was an ...
- NaturalShrimp: The Next Generation Of Shrimp Aquacultureon December 29, 2020 at 8:09 pm
They can be illiquid which tends to increase ... the first of its kind in the country. Puerto Rico currently has zero domestic shrimp production. As you can see, there has been progress made ...
- 7 Lesser-Known Acne-Fighting Ingredients You Haven't Triedon December 27, 2020 at 4:00 pm
Although there has ... increase your dosage). "Propionibacterium acnes and Staphylococcus epidermidis, two of the major acne-associated bacteria, have been shown to have developed antibiotic ...
- Antibiotics in chicken a cause for concern? And five other questions about poultry todayon October 12, 2020 at 4:11 pm
Known as broilers, they are bred for meat production ... its website. Nonetheless, poultry treated with antibiotics “may not be processed for food until a specified withdrawal period has been ...
- Pork chops and ground pork contaminated with bacteriaon August 18, 2020 at 8:52 am
Some of the bacteria we found in 198 samples proved to be resistant to antibiotics commonly used ... FDA-approved feed supplement that has been widely used in the hog-farming industry for many ...
- Infections and dementiaon August 17, 2020 at 6:54 am
Several infections have been suggested to increase risk of Alzheimer's disease ... One trial giving people with mild to moderate dementia a combination of antibiotics found they had smaller decline in ...
- Justin Trudeau, Jane Goodall and Others on Their Big Ideas For Changing the 2020son August 16, 2020 at 4:51 am
But in an industry known for its ... that has failed treatment with last-resort antibiotics in at least 10 countries. If it works, this partnership could be a model for how to increase access ...
