The antibiotic planosporicin is produced by the soil bacterium Planomonospora alba
An antibiotic has been found to stimulate its own production.
The findings, to be published in PNAS, could make it easier to scale up antibiotic production for commercialisation.
Scientists Dr Emma Sherwood and Professor Mervyn Bibb from the John Innes Centre were able to use their discovery of how the antibiotic is naturally produced to markedly increase the level of production.
“We have shown for the first time that an antibiotic with clinical potential can act as signalling molecule to trigger its own synthesis,” said Professor Bibb.
The antibiotic called planosporicin is produced by a soil bacterium called Planomonospora alba. When nutrients become limited, a small amount of the antibiotic is produced. The antibiotic is then able to trigger a mechanism which coordinates its own production throughout the bacterial population resulting in high levels.
“A frequent stumbling block in developing a natural product for commercialisation is being able to provide enough material for clinical trials,” said Professor Bibb.
“Our work shows with the right understanding it is possible to increase productivity very dramatically in a targeted and knowledge-based manner.”
The Latest Bing News on:
Antibiotic production
- Antibiotic-resistant strains of staph bacteria may be spreading between pigs raised in factory farmson March 5, 2021 at 9:48 am
DNA sequencing of bacteria found in pigs and humans in rural eastern North Carolina, an area with concentrated industrial-scale pig-farming, suggests that multidrug-resistant Staphylococcus aureus ...
- How an 'antibiotic' helps bacteria eaton March 5, 2021 at 5:03 am
For years, scientists have known that certain bacteria produce molecules that are toxic to other bacteria when there is competition for food and space. Now, Caltech researchers have discovered these ...
- NAE production uncovers water quality challengeson March 4, 2021 at 7:05 am
I rarely get on a soap box, but I’m going to make an exception in this case. As an industry, if we’re going to continue with “no antibiotics ever” (NAE) production, we have to know the quality of wate ...
- Research Roundup: Covid, Antibiotic Use; Proton Pump Inhibitors; And Fluon March 3, 2021 at 10:24 pm
National Safety Program Linked To Reduced Hospital Antibiotic Use Implementation of a national safety program that helps US hospitals to establish antibiotic stewardship programs (ASPs) and clinicians ...
- Antibiotic-resistant slime: the problem with Pelon March 2, 2021 at 8:58 am
Antibiotic-resistant slime that enables P. aeruginosa to form a protective biofilm has been studied to see the key components and formation.
- Inflammation in children with cystic fibrosis: contribution of bacterial production of long-chain fatty acidson March 2, 2021 at 7:30 am
Cystic fibrosis (CF) affects >70,000 people worldwide, yet the microbiologic trigger for pulmonary exacerbations (PExs) remains unknown. The objective of this study was to identify changes in ...
- Popeyes Announces Plans To Remove Artificial Ingredients, Antibioticson March 2, 2021 at 6:00 am
Popeyes announced new food quality and sustainability commitments as part of a 5-year plan facilitated by parent company Restaurant Brands International. Those commitments extend from its food to its ...
- Commonly used sweeteners may promote antibiotic resistanceon February 28, 2021 at 12:14 pm
Researchers in Australia have conducted a study showing that commonly used nonnutritive sweeteners can promote the spread of antibiotic-resistant genes in the intestine.
- Formulation of a reactive oxygen producing calcium sulphate cement as an anti-bacterial hard tissue scaffoldon February 24, 2021 at 3:22 am
Herein, an antimicrobial honey (SurgihoneyRO-SHRO) has been successfully incorporated into a calcium sulphate (CS) based cement to produce a hard tissue scaffold with the ability to inhibit bacterial ...
- Engineered viruses can fight the rise of antibiotic-resistant bacteriaon February 23, 2021 at 9:02 pm
The threat of antibiotic-resistant bacteria has been growing for years and appears to be getting worse. If COVID-19 taught us one thing, it’s that governments should be prepared for more global public ...
The Latest Google Headlines on:
Antibiotic production
The Latest Bing News on:
Antibiotic has been found to stimulate its own production
- A View From the China Tech Scene - Reactions to Common Western Reactionson March 7, 2021 at 7:31 am
I sat in on an interesting discussion on Clubhouse which opened the floor to address what many participants referred to as "Chinese tech myths." It was a thoughtful, unemotional exchange in English, l ...
- Global players brainstorm to boost Covid vaccine outputon March 7, 2021 at 2:22 am
Global players are gathering online from Monday to brainstorm ways to rapidly boost vaccine production and fight a still-virulent coronavirus that has hobbled the world for 14 months.
- Cultivating animal fat to replace vegetable oils in plant-based meat: ‘Nobody wants a burger that tastes of coconut’on March 4, 2021 at 7:56 am
London-based start-up Hoxton Farms is cultivating animal fat for plant-based meat alternatives. What is the secret to the duo’s competitive edge? Computational biology, the founders tell FoodNavigator ...
- What Happens To Your Body When You Start Taking Probioticson March 1, 2021 at 6:08 am
Whether you just started taking probiotics or you're still researching, here are some physical effects you need to know about.
- Citrus Growers May Soon Have a New Way to Fight Back Against A Deadly Enemyon February 28, 2021 at 6:00 pm
The Asian citrus psyllid fills its stomach by feeding on the leaves and stems of citrus trees. The tiny brown insects infect the trees with bacteria that cause citrus greening, a disease that makes ...
- Company's Antibiotic-Free Livestock Feed Product Shows Positive Results in Subclinical Mastitis Dairy Trialon February 21, 2021 at 4:00 pm
New Zealand OxC-betaT™ Livestock Dairy Trial for use against sub-clinical mastitis has been published in a top-tier international veterinary science journal. In a news release, Avivagen Inc. (VIV:TSX.
- 15 Common Illnesses That Affect Dogs — And How to Prevent Themon February 18, 2021 at 3:30 pm
Dogs have been our most faithful and ... The location of the hot spot can help determine its cause. Treatment can range from topical medications to antibiotics depending on the severity of the ...
- Preserving Antibiotics, Rationallyon February 17, 2021 at 4:00 pm
1 If we multiply this increase ... remove “production” uses from labeling within 3 years. In Europe, the use of antibiotics for growth promotion in animals has been banned, a move that has ...
- Campylobacter strains exchange genes, can become more virulent and antibiotic resistanton February 16, 2021 at 9:41 am
New research from North Carolina State University has found that Campylobacter bacteria persist throughout poultry production ... have the potential to increase its virulence and drug resistance ...
- How gut microbes could drive brain disorderson February 7, 2021 at 4:00 pm
In 2006, soon after she launched her own laboratory ... looking at microbes that cause the disorder, he has found one that might treat its symptoms. Costa-Mattioli stumbled on this bacterium ...
