The antibiotic planosporicin is produced by the soil bacterium Planomonospora alba
An antibiotic has been found to stimulate its own production.
The findings, to be published in PNAS, could make it easier to scale up antibiotic production for commercialisation.
Scientists Dr Emma Sherwood and Professor Mervyn Bibb from the John Innes Centre were able to use their discovery of how the antibiotic is naturally produced to markedly increase the level of production.
“We have shown for the first time that an antibiotic with clinical potential can act as signalling molecule to trigger its own synthesis,” said Professor Bibb.
The antibiotic called planosporicin is produced by a soil bacterium called Planomonospora alba. When nutrients become limited, a small amount of the antibiotic is produced. The antibiotic is then able to trigger a mechanism which coordinates its own production throughout the bacterial population resulting in high levels.
“A frequent stumbling block in developing a natural product for commercialisation is being able to provide enough material for clinical trials,” said Professor Bibb.
“Our work shows with the right understanding it is possible to increase productivity very dramatically in a targeted and knowledge-based manner.”
The Latest Bing News on:
Antibiotic production
- Centrient Pharmaceuticals achieves milestone in antibiotics clean productionon May 19, 2022 at 3:06 am
Centrient Pharmaceuticals has announced 100 per cent compliance with the stringent Predicted No Effect Concentration (PNEC) discharge targets set by the AMR Industry Alliance for clean manufacturing ...
- Centrient Pharmaceuticals announces its achievement of a significant milestone in the clean production of antibioticson May 19, 2022 at 1:16 am
Being the first company to publicly announce 100% PNEC compliance for its entire oral antibiotics product rangeRijswijk, The Netherlands, May 19, 2022 (GLOBE NEWSWIRE) -- Summary Centrient ...
- Livestock farmers urged to reduce the use of antibioticson May 18, 2022 at 11:06 am
Farmers have been advised to reduce the use of antibiotics in livestock production to increase their export volumes. The world animal protection organization says the high use of antibiotics in animal ...
- Animal Antibiotics and Antimicrobials Market Size, Share, Trends, Global Industry Analysis, Growth, Business Overview, Forecast 2022-2029 – VMRon May 16, 2022 at 11:02 am
The research study presented here is an intelligent take on the Animal Antibiotics and Antimicrobials Market that explains important aspects such as competition, segmentation, and regional growth in ...
- Sask Pork receives $150,000 to evaluate antibiotic use on hog farmson May 16, 2022 at 5:15 am
Antimicrobial resistance associated with antibiotic use in food-producing animals has emerged as a major public health concern. The information generated will help develop provincial baselines, ...
- Antibiotics Induce Invasive Candidiasis in Mice and Humans, Immunotherapy Could Helpon May 16, 2022 at 5:00 am
Exposure to broad-spectrum antibiotics increases susceptibility to Candida albicans infections in mice and humans.
- Carbapenem-Based Antibiotics Global Market Outlook 2022-2028: A US$ 5,346.62 Million Market by 2028on May 13, 2022 at 1:08 am
The carbapenem-based antibiotics market size is projected to reach US$ 5,346.62 million by 2028 from US$ 3,964.57 million in 2021; it is estimated to grow at a CAGR of 4.4% from 2021 to 2028.Generic v ...
- Reducing antibiotic use in broiler production: coccidiosis preventionon May 10, 2022 at 1:05 pm
The production of chickens raised without antibiotics (RWA) in the United States has steadily grown during the last decade, surpassing 50% of total ...
- Bacteriophages as a viable alternative to antibiotics in poultryon May 10, 2022 at 2:05 am
The moment of introducing antibiotics was a turning point in medicine. Antibiotics revolutionized the industry, displacing other methods of combating microorganisms, and contributed to the development ...
- Antibiotics may weaken immune response to childhood vaccineson April 26, 2022 at 5:00 pm
But the study builds on earlier work, in lab animals and one study of adults, hinting at a way that antibiotics could hinder antibody production: The drugs temporarily kill off some of the ...
The Latest Google Headlines on:
Antibiotic production
The Latest Bing News on:
Antibiotic has been found to stimulate its own production
- USDA study links fiber with lower antibiotic resistance in guton May 18, 2022 at 11:10 pm
Healthy adults who eat a diverse diet with at least 8-10 grams of soluble fiber a day have fewer antibiotic-resistant microbes in their guts, according to a study ...
- Go organic and the poorest will suffer the consequenceson May 14, 2022 at 4:01 pm
He managed not to choke on the words. I am thinking of the section of the Queen’s Speech, read out to the Houses of Parliament by the Prince of Wales, that went ...
- Searching for cause of alarming increase in acute severe hepatitis in childrenon May 13, 2022 at 10:22 am
Adenovirus has been found in 75% of affected children ... or should each country process its own samples? There are advantages and disadvantages to both paths. Unfortunately, a lot of bureaucratic ...
- Eating More Soluble Fiber Could Help Make Antibiotics More Effective, According to New Researchon May 13, 2022 at 1:39 am
All of these details are valid to keep in mind, but regardless of the eating pattern you lean into, there's one very important detail that you might want to prioritize: fiber. Previously, we've shared ...
- Food Labels: Seals & Claimson May 9, 2022 at 1:19 am
The Goal: A Safer and Healthier Food System Since its inception in 1936, CR has been working with ... in the "raised without antibiotics" example above, our 2019 survey found that 55 percent ...
- Lemon water won't detox or energize you, but it may affect your body in other wayson May 5, 2022 at 5:00 pm
Lemon juice may have other benefits, but research so far has been mixed. One study found people with ... sugar-free gum afterwards to stimulate saliva production avoid brushing your teeth ...
- Paratek Pharmaceuticals (PRTK) Q1 2022 Earnings Call Transcripton May 5, 2022 at 9:31 am
We believe this growth would have been even ... sputum production, chest pain, etc.. And you couple that with the synergism studies, and the lack of antagonism data that we've generated with NUZYRA, ...
- Non-Therapeutic Antibiotics for Food Animals Market : Current Impact to Make Big Changes 2022-2028 with Fastest Growing Regions and Countries Dataon April 27, 2022 at 3:48 am
This report records historical and forecasts market by region with its ... antibiotics are administered at sub therapeutic levels in order to increase feed conversion rate. In order to have ...
- Top Bladder Control Supplements: Best UTI Support Pills For Urinary Tract Infectionson April 13, 2022 at 10:08 am
Infection recurrence is typical after antibiotic ... increase in sex urge and pleasure during ejaculation, unlike anything they’ve felt previously. The unique combination of components has been ...
- Mutations and Evolutionon March 25, 2017 at 2:34 am
No other way had ever been found to explain the exquisite adaptations ... that is resistant to the antibiotic and that has its chance to multiply once the sensitive population is eliminated ...
