The antibiotic planosporicin is produced by the soil bacterium Planomonospora alba
An antibiotic has been found to stimulate its own production.
The findings, to be published in PNAS, could make it easier to scale up antibiotic production for commercialisation.
Scientists Dr Emma Sherwood and Professor Mervyn Bibb from the John Innes Centre were able to use their discovery of how the antibiotic is naturally produced to markedly increase the level of production.
“We have shown for the first time that an antibiotic with clinical potential can act as signalling molecule to trigger its own synthesis,” said Professor Bibb.
The antibiotic called planosporicin is produced by a soil bacterium called Planomonospora alba. When nutrients become limited, a small amount of the antibiotic is produced. The antibiotic is then able to trigger a mechanism which coordinates its own production throughout the bacterial population resulting in high levels.
“A frequent stumbling block in developing a natural product for commercialisation is being able to provide enough material for clinical trials,” said Professor Bibb.
“Our work shows with the right understanding it is possible to increase productivity very dramatically in a targeted and knowledge-based manner.”
The Latest Bing News on:
Antibiotic production
- If you think you know what’s in the chicken gut, think again!on April 15, 2021 at 1:44 pm
New study reveals numerous hitherto unknown bacteria living in the poultry gut, shining a light on the path to developing better management strategies.
- How Plant 'Vaccines' Could Save Us From a World Without Fruiton April 15, 2021 at 1:00 pm
Researchers are formulating unconventional solutions for tree diseases that harm beloved foods like oranges and chocolate. These include a potential RNA therapy, similar to certain COVID-19 vaccines.
- Yeast in kefir drink combats disease-causing bacteriaon April 15, 2021 at 9:00 am
A study shows that a substance in the drink kefir can help combat disease-causing, antibiotic resistant bacteria by disrupting their communication.
- Nanotech Layer Placed On Wound Dressings Kills Antibiotic-Resistant Bacteria With 99% Effectivenesson April 14, 2021 at 8:34 am
Despite stark warnings from microbiologists for the last decade, the world is still far too reliant on antibiotics. From prescribing them for diseases that ...
- Spraying antibiotics on citrus trees is how we get more resistant superbugs | Commentaryon April 14, 2021 at 6:19 am
Two writers warn of the danger of spraying medical antibiotics on citrus trees to stop the greening disease. One big problem is creating more anti-biotic resistant "superbugs." ...
- Do not use antibiotics for egg boost – FAO advices farmerson April 13, 2021 at 4:33 am
The Food and Agricultural Organisation (FAO) is advising farmers to desist from using antibiotics to boost egg production. The National Project Coordinator for Antimicrobial Resistance at FAO, Kofi ...
- Veal calf fattening: It can work with less antibioticson April 8, 2021 at 6:54 am
By adopting a few simple measures, farmers can drastically reduce the use of antibiotics and improve the well-being of their animals without economic disadvantages. This was confirmed in a field trial ...
- Antibiotic Alternatives Stimulate New Product Development in Global Animal Feed Ingredient Marketon April 8, 2021 at 4:03 am
Expand production capacities to meet potential ... Global Animal Feed Ingredient Market Powered by Antibiotic Alternatives and Vertical Integration is the latest addition to Frost & Sullivan's ...
- Bacteria 'shuffle' their genetics around to develop antibiotic resistance on demandon April 7, 2021 at 4:27 am
They can also acquire genes that help them produce antibiotic-destroying molecules, called enzymes. However, all these strategies carry a cost for resistant bacteria. Producing resistance enzymes ...
- China’s overuse of antibiotics in fish products threatens PH’s food safetyon April 5, 2021 at 8:40 pm
China’s reported overuse of antibiotics in its fisheries products threatens food safety in the Philippines, which imports billions worth of seafood products from the world’s second-largest economy ...
The Latest Google Headlines on:
Antibiotic production
The Latest Bing News on:
Antibiotic has been found to stimulate its own production
- Maker Of Mushroom-Sourced Bacon Raises $40 Million To Reach Grocers At Scaleon April 15, 2021 at 3:35 am
Atlast Food Co. taps investors to help it bring sizzling, crispy mycelium styled as bacon to the breakfast table.
- Knoxville Biz Ticker: New dental office coming soon to Farraguton April 14, 2021 at 9:08 am
“With this partnership, quoting BOP has never been easier ... Group Facilities, to increase live event bookings. Oak View Group Facilities, which specializes in providing premium content and ...
- Have $1,000? Consider Buying These 2 Unstoppable Stockson April 14, 2021 at 3:27 am
Although not much can be found at a mere glance, dig deeper and you will find two growth stocks riding solid structural trends. The companies in question are Palantir ( NYSE:PLTR) and OrganiGram ...
- Netflix Banks On Local Language Original Content To Retain Its Market Leadershipon April 11, 2021 at 2:04 am
(NFLX) is the leader of the global over-the-top content streaming industry with over 203 million paying subscribers. The company enjoys first-mover advantages as Netflix was the pioneer in ...
- Future of TV Briefing: How TV shows, movies are managing their returns to productionon April 6, 2021 at 9:09 pm
Following last spring’s physical production hiatus, film and TV projects have largely returned to shooting in studio and on location.
- Environmental antimicrobial resistance driven by poorly managed urban wastewateron March 30, 2021 at 8:35 am
In comparison, they found ... worldwide increase in demand for farmed fish, shrimp and other shellfish has led to the widespread use of antibiotics in aquaculture, and there have been concerns ...
- C.diff Captures Blood Cell Cofactor to Build Defensive Shieldon March 22, 2021 at 6:48 am
The research team found that C.diff exposed to heme increases expression of a protein system that had not been ... our own cells as a shield to protect against our innate immune response,” Skaar said ...
- Preserving Antibiotics, Rationallyon March 17, 2021 at 5:00 pm
1 If we multiply this increase ... remove “production” uses from labeling within 3 years. In Europe, the use of antibiotics for growth promotion in animals has been banned, a move that has ...
- How Can We Control Antibiotic-Resistant Bacteria?on March 15, 2021 at 3:03 pm
Since the monumental discovery of penicillin nearly a century ago, many more types of antibiotics have been developed with ... each department collects its own data and the cooperation between ...
