Researchers from Case Western Reserve University School of Medicine have developed an unprecedented approach to restore nitric oxide (NO) to donated blood, a breakthrough that could dramatically reduce harmful effects from transfusions.
Jonathan Stamler, MD, and colleagues from Case Western Reserve School of Medicine and from Duke University Medical Center describe their findings in the June 24 issue of PNAS: Proceedings of the National Academy of Sciences of the United States of America. Stamler and his colleagues report that restoring blood levels of NO in animals prior to transfusion improved their tissue blood flow, oxygen delivery, and kidney function.
Patients in the U.S. receive approximately 15 million blood transfusions a year. The procedure is often used to replace blood lost through trauma, but also can supplement shortages in a patient’s own ability to produce blood due to cancer and other diseases. Increasingly, medical research publications associate transfusions with harmful consequences including heart attacks, renal failure, and death. A compelling explanation put forward in the literature is that the quantity of NO declines rapidly after donation because it has a short lifespan. Normally, NO dilates blood vessels and allows red blood cells to access tissue and deliver oxygen.
In the blood, NO exists in a bioactive form called S-nitrosohemoglobin (SNO-Hb). The unique process Stamler and team developed to restore SNO-Hb — so-called renitrosylation therapy — could have significant benefits for millions of patients.
“Inasmuch of the world’s supply of banked blood is deficient in SNO-Hb, efforts to restore its levels may hold great therapeutic promise,” said Stamler, director, Institute for Transformative Molecular Medicine and the Robert S. and Sylvia K. Reitman Family Foundation Distinguished Chair in Cardiovascular Innovation, Case Western Reserve School of Medicine and University Hospitals (UH) Case Medical Center, and director, Harrington Discovery Institute, UH Case Medical Center.
“One important aspect of our study is the insight that knowledge of banked blood’s SNO-Hb status may be used to judge the efficacy of a transfusion,” Stamler said.
This information would allow physicians to discriminate between blood donations that may cause harm versus those that will have restorative effects following transfusion.
The research team hypothesized that the loss of NO compromises the ability to dilate blood vessels and thereby deliver oxygen to tissues, which is critical for survival. Red blood cells lacking NO instead would plug small blood vessels and cause heart attacks and kidney failure. In contrast, restoration of NO would ensure oxygen delivery.
The study, funded by the National Heart Lung and Blood Institute (NHLBI), found that mice, rats and sheep transfused with untreated banked blood had decreased oxygen levels in skeletal muscle and other tissues—exactly the opposite of what would have been predicted. By contrast, in animals transfused with renitrosylated (NO repleted) red blood cells, tissue oxygenation improved. In addition, researchers applied the same treatment to anemic animals and found improved blood flow, tissue oxygenation, and kidney function.
Stamler explained that these results demonstrate that restoration of blood NO levels may be useful in treating and preventing a wide variety of conditions, including heart attacks and strokes, and kidney damage following surgery. The findings also may offer new promise for patients with sickle disease, malaria and other blood disorders. In addition, the data suggest that Stamler’s therapeutic is a simple way to reverse the potential toxicity of regular blood transfusions.
The Latest Bing News on:
- Bill to change blood donation rules fails in the Iowa Houseon February 27, 2024 at 8:37 pm
A bill that would change blood donation rules failed to advance through an Iowa House subcommittee on Tuesday. SF 2369 would have required blood banks and hospitals to allow anyone to donate blood for ...
- Survey: 80% of ex-Jehovah’s Witnesses held ‘no blood cards’on February 26, 2024 at 4:00 pm
As part of a survey documenting abuse among Jehovah's Witnesses, 81 percent of second-generation followers report possessing cards showing their refusal to receive blood transfusions. According to ...
- North East Sickle Cell Disease patients to benefit from new blood transfusion machineson February 26, 2024 at 10:02 am
T hree new potentially life-saving blood exchange machines for people with sickle cell disease will be available in Newcastle and Teesside as part of a £1.5m expansion in care fo ...
- Fact check: Are COVID vaccine recipients ineligible to donate blood in NC?on February 26, 2024 at 7:08 am
An ongoing national blood shortage could delay critical medical procedures, Dr. Nick Bandarenko, Duke Health’s medical director of transfusion services, told ABC11 last month. “Surgery, transplant or ...
- Medics Set Up Blood Transfusion Station Near Donbas Front Lineon February 25, 2024 at 1:01 pm
When Ukrainian soldiers are wounded during combat, they are taken to what is called a stabilization point, where combat medics take care of them. Now, thanks to overseas donors, medics in Ukraine's ...
- Arizona is in critical need of blood donations for sickle cell disease patientson February 22, 2024 at 6:58 pm
A lapse in blood donations has caused a critical blood shortage in Arizona and is affecting sickle cell disease patients. Maintaining a diverse blood supply is especially important for African ...
- Medics Set Up Blood Transfusion Station Near Donbas Front Lineon February 21, 2024 at 7:31 am
Now, thanks to overseas donors, medics at one of the stabilization points in Ukraine's Donbas region can perform blood transfusions. Anna Kosstutschenko has the story. VOA footage by Pavel ...
- Chicago Bears legend Steve 'Mongo' McMichael receives blood transfusion, diagnosed with MRSAon February 18, 2024 at 11:40 am
McMichael, who played on the Super Bowl-winning 1985 Bears squad learned last week he would be inducted into the Pro Football Hall of Fame.
- Steve McMichael gets blood transfusion, has MRSA infectionon February 18, 2024 at 2:35 am
Steve McMichael, who was elected to the Pro Football Hall of Fame as he battles ALS, has had a health setback.
- Steve ‘Mongo’ McMichael Has MRSA, Undergoing Blood Transfusionon February 17, 2024 at 5:32 pm
Steve ‘Mongo’ McMichael has been diagnosed with MRSA, and is currently getting a blood transfusion following his hospitalization this week. After being hospitalized with an infection, NFL legend ...
The Latest Google Headlines on:
[google_news title=”” keyword=”Blood Transfusions” num_posts=”10″ blurb_length=”0″ show_thumb=”left”]
The Latest Bing News on:
Restoring blood levels of NO
- PMQs live: Starmer asks Sunak if he backs Farage to 'restore Tory party' - and attacks Truss over 'conspiracies'on February 28, 2024 at 5:02 am
Prince Harry to seek to appeal High Court loss against Home Office over taxpayer-funded security As we reported this morning, Prince Harry lost his High Court challenge against the Home Office over ...
- The special glasses that can restore vision where normal ones fail, and why almost no one (including eye doctors) has heard of themon February 21, 2024 at 12:18 pm
In July 2021, Bramer suffered what doctors diagnosed as an ocular stroke – they said a small particle of plaque must have blocked blood flow to the optic nerve ... cone dystrophy – that reduce vision ...
- Restoring the Past Won’t Liberate Palestineon February 17, 2024 at 11:24 pm
Fanon, a psychiatrist turned anticolonial political figure, had a lot to say about violence. In his book “The Wretched of the Earth” he wrote that “violence is a cleansing force. It frees the native ...
- Combo of blood thinners, clot-busting meds doesn't benefit stroke patientson February 8, 2024 at 2:58 am
Adding blood thinners to clot-busting drugs does not ... trial looking into the combo for stroke treatment after finding no apparent benefit for the first 500 participants out of the planned ...
- Alteplase Versus Urokinase in Restoring Blood Flow in Hemodialysis-Catheter Thrombosison February 5, 2024 at 4:01 pm
Information collected included patient demographics, etiology of end-stage renal disease, age of catheter at time of thrombosis, pretreatment and posttreatment hemodialysis blood-flow rates ...
- Radiant Ease CBD Gummies [Fraudulent Exposed 2024] Therazen CBD Gummies for Blood Sugar Really Works?on February 2, 2024 at 3:55 am
It promises to restore the wellbeing while maintaining a healthy blood pressure levels by regulating the ... Rest assured, there are no side effects associated with the consumption of Radiant ...
- SugaSafe Reviews: Safe Blood Sugar Remedy or False Claims?on January 29, 2024 at 5:30 pm
With B vitamins, various herbal extracts, vitamins, and minerals, consumers can restore the balance that their blood sugar levels need to ... as it’s supposed to. No blood sugar supplement ...
- Alteplase Versus Urokinase in Restoring Blood Flow in Hemodialysis-Catheter Thrombosison January 28, 2024 at 4:00 pm
The effectiveness of alteplase and urokinase in restoring adequate hemodialysis ... in both treatment groups required no further interventions. Hemodialysis blood-flow rates increased after ...
- Restoring immune surveillance to tackle age-related diseaseson December 1, 2023 at 4:57 am
“It is difficult to target senescent cells directly since there is no universal method to identify ... leading to durable improvements in blood glucose levels, insulin resistance and HbA1c ...
- 6 light exercises you can do to control high blood pressureon October 11, 2023 at 11:30 pm
According to the World Health Organization (WHO), hypertension, or high blood pressure (BP), affects an estimated 1.28 billion adults aged 30-79 years globally. Following a poor diet with excessive ...
The Latest Google Headlines on:
Restoring blood levels of NO
[google_news title=”” keyword=”restoring blood levels of NO” num_posts=”10″ blurb_length=”0″ show_thumb=”left”]