An estimated 4,837,000 asthmatics with allergic bronchopulmonary aspergillosis (ABPA) could benefit substantially from antifungal treatment, say researchers from the University of Toronto and Manchester University.
Their work, published today in the journal Medical Mycology, has also re-estimated the total number of asthmatics worldwide – to reveal a staggering 193 million sufferers. Twenty-four million asthma sufferers live in the United States, 20 million each in India and China, and seven million in the United Kingdom.
Clinical studies have shown that oral antifungal drugs significantly improve symptoms and asthma control in asthmatics with ABPA, treatment endorsed by the Cochrane Collaboration. This is the first time that a global estimate of ABPA numbers has been made.
In national league tables of asthma rates in adults, only Australia and Sweden have a higher prevalence than the UK. In global league tables of ABPA occurrence, New Zealand tops the list with a 3.5% rate in new patients attending chest clinics at hospitals. The rates were 2.6% in Cape Town, 2.3% in Saudi Arabia, 2.5% in China and 0.7% in an older study from Ireland. No population-based studies have been done.
In addition to standard asthma therapy, the antifungal therapy used is itraconazole – now a generic, inexpensive antifungal – with a response rate of 60%. The researchers also found that antifungal therapy also benefits patients with severe asthma sensitized to fungi, called SAFS.
Alternatives include voriconazole and posaconazole, which have 75-80% response rates. In a recent assessment of voriconazole and posaconazole for both ABPA and SAFS, 75% of patients were able to stop taking oral corticosteroids, a major benefit, and 38% of patients had their asthma severity downgraded on antifungal therapy.
Professor David Denning, professor of medicine and medical mycology at the University of Manchester and Director of the University Hospital of South Manchester’s National Aspergillosis Centre, led the study into the total number of asthmatics worldwide. He said the study results implied that asthma admissions and deaths could be avoided with more extensive use of antifungal therapy.
“We were surprised by the number of patients with ABPA, and by the lack of community based studies done,” he said. “Our National Aspergillosis Centre treats hundreds of these patients each year, generally with major improvement, and so a conscious program to seek out ABPA from all asthmatics is required.”
The Latest Bing News on:
- Cyclosporine: hope for severe COVID-19?on January 15, 2021 at 4:00 pm
To the editor, We are in the midst of the COVID-19 pandemic from the SARS CoV-2. This has taken at the time of writing 0.8 million lives which has put the medical fraternity under extreme challenge to ...
- Sepsis Management Analysis, 2020 Report with Focus on Treatments - ResearchAndMarkets.comon January 13, 2021 at 10:55 pm
Treatments” report has been added to ResearchAndMarkets.com’s offering. This research study begins by highlighting the current status of sepsis treatment, such as antibiotics used with different kinds ...
- Candidemia Market Insights, Epidemiology, and Market Forecast to 2030 - ResearchAndMarkets.comon January 13, 2021 at 10:46 pm
Market Insights, Epidemiology, and Market Forecast-2030” drug pipelines has been added to ResearchAndMarkets.com’s offering. The Candidemia market report provides current treatment practices, emerging ...
- 'Magic mushrooms' grow in man's blood after injection with shroom teaon January 13, 2021 at 11:48 am
A man brewed a tea from "magic mushrooms" and injected the concoction into his veins; several days later, he ended up at the emergency department with the fungus growing in his blood. The man spent 22 ...
- Does Boric Acid Work for Yeast Infections and Bacterial Vaginosis?on January 12, 2021 at 3:38 pm
If you've had a yeast infection in the past, you know the drill. As soon as you develop symptoms such as itching and burning down there, you head to your local drugstore, grab an OTC yeast infection ...
- Increasing Availability of FDA-approved Drugs and Surgical Therapies Augmenting Basal Cell Carcinoma Treatment Market Growthon January 12, 2021 at 4:21 am
Surgical treatment dominates with the highest revenue amongst all treatment options in the basal cell carcinoma treatment market with a projected value of US 6 billion by the end of 2025 Mohs surgery ...
- Basilea reports preliminary 2020 revenue and portfolio progresson January 11, 2021 at 9:26 am
Significant progress made in the commercialization of Cresemba and Zevtera with 2020 revenue contributions of CHF 112 million in line with ...
- Press Release: Basilea's partner Asahi Kasei Pharma completes patient enrolment in phase 3 study with antifungal isavuconazole (Cresemba(R)) in Japanon January 6, 2021 at 10:57 pm
DJ Basilea's partner Asahi Kasei Pharma completes patient enrolment in phase 3 study with antifungal isavuconazole (Cresemba(R)) in Japan (MORE TO FOLLOW) ...
- Basilea’s partner Asahi Kasei Pharma completes patient enrolment in phase 3 study with antifungal isavuconazole (Cresemba®) in Japanon January 6, 2021 at 4:00 pm
(SIX: BSLN) reported today that patient enrolment has been completed in the phase 3 study with the antifungal isavuconazole (Cresemba ®), which is conducted in Japan by Corporation (Asahi Kasei Pharma ...
- A Patients Guide to Vaginal Yeast Infection Medicationson December 24, 2020 at 9:33 am
These over-the-counter antifungal treatments are available as ... Avoid vaginal intercourse while treating a yeast infection, as some treatment products may damage condoms or diaphragms and ...
The Latest Google Headlines on:
The Latest Bing News on:
- Global Asthma Clinical Trial Pipeline Report 2021 - ResearchAndMarkets.comon January 20, 2021 at 2:17 am
The "Global Asthma Clinical Trial Pipeline Highlights - 2021" report has been added to ResearchAndMarkets.com's offering. Asthma Pipeline Highlights - 2021, provides the most up-to-date information on ...
- Why asthma doesn’t qualify you for the COVID vaccine just yeton January 19, 2021 at 7:38 am
When New Jersey’s expanded coronavirus vaccine eligibility rules took effect Thursday, those with asthma were not included. This came as a surprise to some, since adults with asthma “might be at an ...
- United States Asthma Market and Competitive Landscape Report 2021on January 19, 2021 at 1:48 am
The "US Asthma Market and Competitive Landscape - 2021" report has been added to ResearchAndMarkets.com's offering.
- Benefits of Kiwi: From Skincare to Treating Asthma – 6 Reasons to Include This Chinese Fruit in Your Dieton January 16, 2021 at 12:55 am
Right from treating Asthma and improving vision to helping in making your skin look better than before, there are many reasons for including Kiwi in your diet. Choose yours!
- Study Links Higher Meat Consumption With Increased Risk of Childhood Asthmaon January 14, 2021 at 2:33 pm
Experts say the data is preliminary and shouldn’t change dietary behavior yet, but more research is warranted.
- Knopp’s oral asthma drug hits primary endpoint in phase 2on January 14, 2021 at 6:18 am
A phase 2 clinical trial of Knopp Biosciences’ dexpramipexole in patients with moderate-to-severe eosinophilic asthma has met its primary endpoint. Knopp said the data support further development of a ...
- Asthma Guideline Update Aims to Improve Care, Shared Decisionson January 13, 2021 at 5:43 pm
Updated asthma management guidelines will influence treatment of mild and persistent asthma in more patient-centered ways, says an FP who contributed to the work.
- Inhaled Therapy Disrupts Excess Mucus Production in Allergic Asthma Modelon January 13, 2021 at 1:00 pm
Researchers at the University of Colorado Anschutz Medical Campus report that they have broken up deadly mucus secretions in the lungs, which can be fatal for asthma patients, at the molecular level ...
- Lipid biomarkers in urine can determine the type of asthmaon January 13, 2021 at 9:46 am
In a new study, researchers at Karolinska Institutet in Sweden have used a urine test to identify and verify a patient's type of asthma. The study, which has been published in the American Journal of ...
- Scientists reverse deadly impacts of asthma in miceon January 13, 2021 at 7:52 am
Mucus in the lungs can be fatal for asthma patients, but scientists at the University of Colorado Anschutz Medical Campus have broken up those secretions at the molecular level and reversed their ...