English: A 68-year-old diabetic female on dialysis presented with a chronic right heel ulcer (3.4 cm X 3.1 cm) of greater than 3 months duration. Photograph of the wound after thorough wound bed preparation over the course of 2 weeks. (Photo credit: Wikipedia)
Every 20 seconds, a limb is lost as a consequence of diabetic foot ulcer that does not heal.
To date, medical solutions that can change this situation are very limited. In his doctoral thesis Yue Shen from the Industrial Doctoral School and the Department of Medical Biochemistry and Biophysics at Umeå University presented a novel medicine for chronic wound treatment that may completely change the lives of millions of patients.
Diabetic wounds are the most severe type of chronic wounds that largely impair the quality of life in patients and inflict an enormous burden on the healthcare system. World-wide, there are more than 350 million diabetic patients and about 20% of them develop diabetic foot ulcers that often do not heal, which eventually lead to amputation. Chronic eardrum perforations are another type of chronic wounds. Today the only existing treatment of chronic eardrum perforations is through surgery.
In his thesis, Yue Shen demonstrates that plasminogen, a well-known plasma protein, acts as a key regulatory molecule of inflammation that can be used to treat different types of chronic wounds including diabetic wounds and chronic eardrum perforations. Yue Shen demonstrates that the level of plasminogen dramatically increases in and around wounds, which leads to an enhanced inflammation that is required for healing. In diabetic wounds that do not heal, the level of plasminogen does not increase and the inflammatory response is suppressed. When plasminogen is injected around diabetic wounds, the healing process starts and the wounds eventually heal fully. In chronic eardrum perforations, local injection and topical application of plasminogen also stimulates the healing and leads to complete healing.
Based on these studies, a controlled clinical study using human plasminogen to treat chronic wounds in humans is now planned.
The Latest Bing News on:
Chronic wounds
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The Latest Google Headlines on:
Chronic wounds
The Latest Bing News on:
Chronic wound treatment
- More research, training and innovation to improve chronic wound care for elderly patients in S'poreon April 14, 2021 at 4:20 am
Wounds such as bed sores and diabetic foot ulcers can lead to longer hospital stays.. Read more at straitstimes.com.
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Rising prevalence of diabetes will help the global “Active Wound Care Market 2021” gain momentum, predicts Fortune ...
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