Progression of Huntington’s Diesase. A microscope image of Medium spiny neurons (yellow) with nuclear inclusions (orange), which occur as part of the disease process. (Photo credit: Wikipedia)
Researchers at Lund University have succeeded in preventing very early symptoms of Huntington’s disease, depression and anxiety, by deactivating the mutated huntingtin protein in the brains of mice.
“We are the first to show that it is possible to prevent the depression symptoms of Huntington’s disease by deactivating the diseased protein in nerve cell populations in the hypothalamus in the brain. This is hugely exciting and bears out our previous hypotheses”, explains Åsa Petersén, Associate Professor of Neuroscience at Lund University.
Huntington’s is a debilitating disease for which there is still neither cure nor sufficient treatment. The dance-like movements that characterise the disease have long been the focus for researchers, but the emotional problems affect the patient earlier than the motor symptoms. These are now believed to stem from a different part of the brain – the small emotional centre called the hypothalamus.
“Now that we have been able to show in animal experiments that depression and anxiety occur very early in Huntington’s disease, we want to identify more specifically which nerve cells in the hypothalamus are critical in the development of these symptoms. In the long run, this gives us better opportunities to develop more accurate treatments that can attack the mutated huntingtin where it does the most damage”, says Åsa Petersén.
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- Carilion Clinic looking for Huntington’s disease patients for surveyon May 10, 2022 at 5:06 pm
Carilion Clinic is looking for people with Huntington’s disease to participate in a survey to better patients’ care. The survey will look at people’s experience with the disease, quality of life and ...
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- Huntington's disease: what is this rare neurodegenerative disorder?on May 9, 2022 at 9:00 am
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- bit.bio’s New Huntington’s Disease Human Cell Model Set to Accelerate Drug Discovery and Screeningon May 8, 2022 at 11:00 pm
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- Huntington's Disease Newson April 30, 2022 at 5:00 pm
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- ‘A parallel life’: The medical mistake that saw a woman watch her entire family fight incurable brain diseaseon May 18, 2022 at 3:28 am
With Bert showing symptoms of the condition at 64 ... of the condition and encourage desperately needed research to coincide with May being Huntington’s Disease Awareness month. “I want Bert and Elise ...
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Neurocrine Biosciences, Inc. (Nasdaq: NBIX) today announced that it has received Orphan Drug Designation from the U.S. Food and Drug Administration (FDA) for ...
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The report provides a complete analysis of Global Huntington's Disease Treatment Industry. The global huntington's disease treatment market will reach US$ ...
- Huntington's: A complex brain disease that affects movement, thoughts and feelingson May 10, 2022 at 10:54 am
Huntington's disease is hereditary, genetic and usually begins between the ages of 30 and 50. In Sweden, around 1,000 people have the diagnosis and several thousand live with the risk of getting the ...
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- High tea for Huntington's Disease at Orange's Canobolas Hotelon May 2, 2022 at 10:00 am
"Huntington's Disease is often hidden away due to a number of factors. Many are because of the symptoms that Huntington's can display and the way they affect each person," Ms Brooking said.
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cognitive skill and psychiatric symptoms over a period of 30 years. The Neurobiological Predictors of Huntington's Disease (PREDICT) study is an NIH- and Cure HD Initiative-funded multisite ...
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