Two peak flow meters. (Photo credit: Wikipedia)
Researchers said on Tuesday that a new type of asthma drug could be a potential game changer for patients with moderate to severe respiratory disease.
The injectable drug, known as dupilumad, slashed asthmatic episodes by 87 percent in a mid-stage trial of 104 patients. The team wrote about the latest trial’s results in the New England Journal of Medicine (NEJM).
“Asthma that is difficult to treat is increasingly recognized as comprising different phenotypes,” lead author Sally Wenzel, MD, director of the University of Pittsburgh Asthma Institute said. “With this study, we wanted to see whether dupilumab would reduce a surrogate index for asthma exacerbations when given with ICS and LABA and when those two therapies were withdrawn.”
Dupilumad is a fully human monoclonal antibody that thwarts activation of the Th2 immune response implicated in asthma by blocking two cytokines, interleukin-4 and interleukin-13. Researchers performed a 20-week study on patients who had received weekly injections of the drug.
Patients in the study received either dupilumad or a placebo twice a day. During the fourth week, patients were instructed to withdraw LABA, and between weeks six and nine they tapered off ICS. They found that dupilumad provided an 87 percent reduction in protocol defined asthma exacerbations. Moreover, they saw significant improvements for other relevant asthma outcomes like lung functions and morning peak expiatory flow.
The Latest Bing News on:
Asthma
- United States Asthma Market and Competitive Landscape Report 2021on January 19, 2021 at 1:48 am
The "US Asthma Market and Competitive Landscape - 2021" report has been added to ResearchAndMarkets.com's offering.
- Why asthma doesn’t qualify you for the COVID vaccine just yeton January 17, 2021 at 6:30 am
When New Jersey’s expanded coronavirus vaccine eligibility rules took effect Thursday, those with asthma were not included. This came as a surprise to some, since adults with asthma “might be at an ...
- Benefits of Kiwi: From Skincare to Treating Asthma – 6 Reasons to Include This Chinese Fruit in Your Dieton January 16, 2021 at 12:55 am
Right from treating Asthma and improving vision to helping in making your skin look better than before, there are many reasons for including Kiwi in your diet. Choose yours!
- Study Links Higher Meat Consumption With Increased Risk of Childhood Asthmaon January 14, 2021 at 2:33 pm
Experts say the data is preliminary and shouldn’t change dietary behavior yet, but more research is warranted.
- Knopp’s oral asthma drug hits primary endpoint in phase 2on January 14, 2021 at 6:18 am
A phase 2 clinical trial of Knopp Biosciences’ dexpramipexole in patients with moderate-to-severe eosinophilic asthma has met its primary endpoint. Knopp said the data support further development of a ...
- Asthma Guideline Update Aims to Improve Care, Shared Decisionson January 13, 2021 at 5:43 pm
Updated asthma management guidelines will influence treatment of mild and persistent asthma in more patient-centered ways, says an FP who contributed to the work.
- Inhaled Therapy Disrupts Excess Mucus Production in Allergic Asthma Modelon January 13, 2021 at 1:00 pm
Researchers at the University of Colorado Anschutz Medical Campus report that they have broken up deadly mucus secretions in the lungs, which can be fatal for asthma patients, at the molecular level ...
- Man With Severe Asthma Saved From Deportation Due To Air Pollution Concernson January 13, 2021 at 8:05 am
A court in France has saved a man from being deported because of his poor health condition and the poor air quality in his country of birth, which would ex ...
- Scientists reverse deadly impacts of asthma in miceon January 13, 2021 at 7:52 am
Mucus in the lungs can be fatal for asthma patients, but scientists at the University of Colorado Anschutz Medical Campus have broken up those secretions at the molecular level and reversed their ...
- Lipid biomarkers in urine can determine the type of asthmaon January 13, 2021 at 6:49 am
In a new study, researchers at Karolinska Institutet in Sweden have used a urine test to identify and verify a patient's type of asthma. The study, which has been published in the , lays the ...
The Latest Google Headlines on:
Asthma
The Latest Bing News on:
Asthma drug
- Sinus Therapeutic Drugs Market will reach US$ 4.29 Bn by 2030 – Future Market Insightson January 19, 2021 at 5:30 am
According to a new market study by Future Market Insights (FMI), the sinus therapeutic drugs market will expand at a healthy CAGR of 6.3% between 2020 and ...
- United States Asthma Market and Competitive Landscape Report 2021on January 19, 2021 at 1:48 am
The "US Asthma Market and Competitive Landscape - 2021" report has been added to ResearchAndMarkets.com's offering.
- Knopp Biosciences Announces Positive Top-Line Results from the Phase 2 EXHALE Trial of Oral Dexpramipexole in Moderate-to-Severe Eosinophilic Asthmaon January 15, 2021 at 1:06 am
Knopp Biosciences LLC today announced positive top-line results in a Phase 2 dose-ranging trial of the novel oral drug dexpramipexole in patients with moderate-to-severe eosinophilic asthma. The ...
- Knopp’s oral asthma drug hits primary endpoint in phase 2on January 14, 2021 at 6:18 am
A phase 2 clinical trial of Knopp Biosciences’ dexpramipexole in patients with moderate-to-severe eosinophilic asthma has met its primary endpoint. Knopp said the data support further development of a ...
- Miami Doctor Falsified Clinical Trial Data For Asthma Meds: DOJon January 13, 2021 at 1:54 pm
Dr. Yvelice Villaman Bencosme of Miami falsified clinical trial data for a children's asthma medication, the DOJ said.
- Inhaled Therapy Disrupts Excess Mucus Production in Allergic Asthma Modelon January 13, 2021 at 1:00 pm
Researchers at the University of Colorado Anschutz Medical Campus report that they have broken up deadly mucus secretions in the lungs, which can be fatal for asthma patients, at the molecular level ...
- Anti Asthma Drugs Market -Global Anti Asthma Drugs Market Size, Development Status, Top Manufacturers, and Forecastson January 13, 2021 at 10:15 am
With the number of asthma patients rising due to pollution, the Global Anti-Asthma Drugs Market likely to grow with ...
- Global Asthma Drug Forecast to 2029 - GlaxoSmithKline and AstraZeneca Lead the Wayon January 13, 2021 at 3:15 am
Global Drug Forecast and Market Analysis to 2029" report has been added to ResearchAndMarkets.com's offering. This model ...
- Miami doctor pleads guilty to falsifying clinical trial data for asthma medicationon January 12, 2021 at 4:13 pm
A Miami pediatrician has pleaded guilty to falsifying clinical trial data for an asthma medication for children and defrauding a pharmaceutical company that commissioned the research.
- Laryngeal control therapy reduces need for asthma drugs in kids with PVFMD: Studyon January 11, 2021 at 12:23 pm
USA: Participation in laryngeal control therapy (LCT) reduces the use of asthma medication in pediatric patients with paradoxical vocal fold motion disorder (PVFMD), finds a recent study in ...
