Two peak flow meters. (Photo credit: Wikipedia)
Researchers said on Tuesday that a new type of asthma drug could be a potential game changer for patients with moderate to severe respiratory disease.
The injectable drug, known as dupilumad, slashed asthmatic episodes by 87 percent in a mid-stage trial of 104 patients. The team wrote about the latest trial’s results in the New England Journal of Medicine (NEJM).
“Asthma that is difficult to treat is increasingly recognized as comprising different phenotypes,” lead author Sally Wenzel, MD, director of the University of Pittsburgh Asthma Institute said. “With this study, we wanted to see whether dupilumab would reduce a surrogate index for asthma exacerbations when given with ICS and LABA and when those two therapies were withdrawn.”
Dupilumad is a fully human monoclonal antibody that thwarts activation of the Th2 immune response implicated in asthma by blocking two cytokines, interleukin-4 and interleukin-13. Researchers performed a 20-week study on patients who had received weekly injections of the drug.
Patients in the study received either dupilumad or a placebo twice a day. During the fourth week, patients were instructed to withdraw LABA, and between weeks six and nine they tapered off ICS. They found that dupilumad provided an 87 percent reduction in protocol defined asthma exacerbations. Moreover, they saw significant improvements for other relevant asthma outcomes like lung functions and morning peak expiatory flow.
The Latest Bing News on:
Asthma
- Zoom-In on Health Equity: AAFA Asks Congress to Tackle Racial Disparities in Asthma and Allergyon April 30, 2021 at 11:26 am
AAFA takes annual advocacy efforts to Capitol Hill with virtual rounds On racial disparities in asthma, AAFA advocate Valerie Vison of Minnesota shared in meetings with staffers from her two Senate ...
- Patients With Asthma Need an Action Planon April 30, 2021 at 5:34 am
Pharmacists can play a vital role by offering inhaler counseling and helping improve adherence, especially during COVID-19.
- Wide receiver Ja'Marr Chase reveals he needed asthma pumps while battling COVID-19on April 29, 2021 at 4:51 pm
Ja'Marr Chase, a wide receiver projected by USA TODAY Sports to go early in the NFL draft, had COVID-19 that required asthma pumps.
- A baby’s first poo reveals if they are at risk of allergies and asthmaon April 29, 2021 at 8:05 am
If the first stool passed by a baby is rich in a diverse set of chemicals, this may encourage the growth of beneficial gut bacteria that support a healthy immune system ...
- What to know about asthma attackson April 28, 2021 at 6:00 pm
During an asthma attack, bronchial tubes tighten, making it very difficult to breathe. Asthma attacks can be life-threatening. Learn more.
- Christmas Eve coke works fire followed by asthma exacerbationson April 28, 2021 at 7:56 am
Asthma exacerbations rose following a catastrophic Christmas Eve fire two years ago that destroyed pollution controls at the Clairton Coke Works—the largest such facility in the nation, a University ...
- Blowing hot and cold over asthma hospitalisationson April 27, 2021 at 5:00 pm
Climate change is among the greatest public health challenges in the 21st century. While there is a general consensus on the rising of global mean temperature,1 whether this warming has caused surface ...
- A cross-sectional analysis of associations between environmental indices and asthma in U.S. counties from 2003 to 2012on April 24, 2021 at 11:59 am
We aim to estimate associations between existing environmental indices and asthma prevalence over a large population and multiple years. Based on data availability, we assessed the predictive ...
- Asthma can be nuisance for some, fatal for otherson April 23, 2021 at 2:00 pm
There are a number of things that can trigger asthma attacks. Among them are seasonal allergies, certain odors, air pollutants and powders. Dr. Peter Boggs, an allergist with Willis Knighton Health ...
- What to know about childhood asthmaon April 21, 2021 at 8:00 pm
Childhood asthma is one of the most common chronic conditions in infants and children. Learn more about the causes, symptoms, and diagnosis of the condition here.
The Latest Google Headlines on:
Asthma
The Latest Bing News on:
Asthma drug
- Deep Breathing Exercises And Asthmaon April 30, 2021 at 9:55 am
Here’s everything you need to know about complementary, alternative, and natural remedies for asthma, including which ones doctors say may actually help with asthma symptoms. Diana Rodriguez By Diana ...
- Patients With Asthma Need an Action Planon April 30, 2021 at 5:34 am
Pharmacists can play a vital role by offering inhaler counseling and helping improve adherence, especially during COVID-19.
- What to know about asthma attackson April 28, 2021 at 6:00 pm
During an asthma attack, bronchial tubes tighten, making it very difficult to breathe. Asthma attacks can be life-threatening. Learn more.
- Asthma Drug Hastens Recovery in COVID-19 Patientson April 26, 2021 at 4:36 am
Inhaled budesonide can enhance recovery in COVID-19 patients aged over 50, according to a study. Early treatment with inhaled budesonide cut recovery time by a median of three days in COVID-19 ...
- Asthma drug can be game-changer for patients with mild COVID symptomson April 25, 2021 at 2:09 am
Experts say the use of asthma inhalers in fighting early Covid-19 infection could reduce the burden on medical infrastructure significantly and prove to be a game-changer.
- Asthma Drug May Be Used To Treat Covid In Maharashtra, Says Top Doctoron April 23, 2021 at 4:32 am
The drug, inhaled budesonide, is likely to be added to the list of medicines that could be used to support treatment of COVID-19 patients.
- Turkish study shows asthma drug molecule may cure COVID-19on April 22, 2021 at 4:01 am
A team of scientists from two Turkish universities has discovered that montelukast, a molecule used in the routine treatment of asthma, has ...
- Global Asthma Treatment Drugs Market Outlook, Industry Analysis and Prospect 2021on April 21, 2021 at 3:55 pm
The Asthma Treatment Drugs market report provides a detailed analysis of global market size, regional and country-level market size, segmentation market growth, market share, competitive Landscape, ...
- COPD and Asthma Drug Devices Market Share 2021: Global Trends, Key Players, Industry Analysis and Forecast to 2027on April 21, 2021 at 1:14 am
COPD and asthma devices market is expected to reach $51,628.58 million by 2027, registering a CAGR of 4% during 2021-2027. Chronic obstructive pulmonary disease (COPD) and asthma devices are used as ...
- Asthma Drugs Market Research Report by Product, by Application - Global Forecast to 2025 - Cumulative Impact of COVID-19on April 20, 2021 at 6:52 pm
This helps organization leaders make better decisions when currency exchange data is readily available.1. The Global Asthma Drugs Market is expected to grow from USD 14,837.58 Million in 2020 to USD ...
