“Most likely, people in the future will take a cocktail of molecules that can slow ageing and prevent common age-related diseases.”
David Sinclair, an Australian scientist and entrepreneur working on increasing human health, productivity, and lifespan, could be close to discovering the fountain of youth, and it’ll come in a tablet.
At TEDxSydney 2013 the Professor of Genetics at Harvard Medical School will share a new concept about why we age and how it should be possible to develop medicines to reverse it.
“There are many molecules we know now of that can slow down aspects of ageing in mice. The question is no longer an ‘if’, but a ‘when’,” says Sinclair. “Most likely, people in the future will take a cocktail of molecules that can slow ageing and prevent common age-related diseases.”
The new class of superdrug – from the man who discovered resveratrol, a plant compound found in red wine, as an anti-ageing molecule – could possibly see people living decades longer.
“We’re not sure how much longer people will live but in mice these molecules prevent many diseases of old age, including diabetes, cancer and heart disease,” he says. “The molecules were initially discovered by studying a longevity gene in yeast cells called SIR2. The new molecules that target the human SIR2 are hundreds of times more potent that these original molecules. These are in early stage clinical trials, so it will be at least a few years before they are on the market.”
Sinclair’s preoccupation with ageing is driven by the belief that this knowledge can be used to prevent and treat both rare and common diseases, helping people live healthier, disease-free lives. His work at Harvard and at a new lab established at the University of New South Wales, focuses on genes and small molecules that mimic exercise and calorie restriction, a diet that slows the pace of ageing in animals.
He says: “Ageing is the root cause of most major diseases. By addressing the root causes of these diseases we should be able to have a large impact on human health. Am I playing God? Absolutely not. I’m no different than other researchers looking for ways to make people healthier for longer. It’s proven that the healthier you make people, the less burden they are on society.”
Not content to stay in the lab, Sinclair has also founded four biotechnology companies. These are Sirtris, which treats age-related diseases and was sold to GlaxoSmithKline for a reported US$720 million in 2008; OvaScience, which aims to improve female reproductive health and IVF; Cobhar to treat type 2 diabetes; and Genocea, which develops vaccines against malaria, chlamydia, tuberculosis, pneumonia, and cancer.
You could say it’s in his genes; Sinclair’s parents are trained biochemists and growing up in St. Ives, in the northern suburbs of Sydney, his parents would talk about their work at the dinner table. He enrolled in a Bachelor of Science at the University of New South Wales. Doing bench research in molecular biology in the lab of Professor Ian Dawes at UNSW, a molecular biologist and geneticist, was a turning point.
“You couldn’t drag me out of the lab after that,” he says.
The Latest Bing News on:
- BENEO survey shows positive ageing driving demand for healthier nutritionon November 29, 2021 at 3:17 am
New research, conducted on behalf of BENEO, reveals consumers are now even more focused on ‘positive’ ageing. The research, carried out by HealthFocus International, includes an exclusive analysis of ...
- What one-child policy? As India’s population growth slows, China-style controls on births called into questionon November 29, 2021 at 3:12 am
India's total fertility rate has dropped below the level needed to maintain a stable population, but it's still on track to become the most populous country Advocates cheered the survey results as a ...
- Booster could be offered to all adults to slow spread of new Covid varianteon November 29, 2021 at 2:29 am
All adults could be offered booster jabs as the government steps up its campaign against a new variant of coronavirus.
- No slowing Jonathan down in Feaster Fiveon November 28, 2021 at 4:36 pm
Haverhill resident Jonathan Dion was there near the front of the pack before the start of Thursday's 34th running of the Feaster Five Road Race. He is 18. He is in the autism spectrum. He attends a ...
- A father and son’s Ice Age plot to slow Siberian thawon November 27, 2021 at 4:01 pm
In one of the planet’s coldest places, 130km south of Russia’s Arctic coast, scientist Sergey Zimov can find no sign of permafrost as global warming permeates Siberia’s soil.As everything from mammoth ...
- Shoppers Say This Anti-Aging Serum Eliminated Their Wrinkles In a Matter of Weeks — and It's On Saleon November 26, 2021 at 12:45 pm
The "miracle" formula contains a combination of retinol and hyaluronic acid to hydrate skin, fade dark spots, and minimize fine lines sans irritation.
- The Best Foods for Men to Slow Aging After 50, Say Dietitianson November 24, 2021 at 5:13 am
As the old saying goes, you are what you eat. So, if your goal is to be more youthful, here are the best foods for men after 50.
- Everyday Habits That Are Aging You Fasteron November 22, 2021 at 6:20 am
Let's face it—we all have a few bad habits we think are harmless enough, but in reality they're not. Many of the bad behaviors we engage in are not only unhealthy, but can speed up the aging process.
- The Best Foods to Slow Aging After 50, Say Dietitianson November 19, 2021 at 5:12 am
These foods are known to slow the aging process after 50 because of their specific vitamins and nutrients found in each type.
- The Best Foods for Women to Slow Aging After 50, Say Dietitianson November 16, 2021 at 12:39 pm
Attention, ladies! Did you know that your diet can actually affect the state of your health as you age? Especially after the age of 50? According to multiple health experts, poor nutrition can ...
The Latest Google Headlines on:
The Latest Bing News on:
Preventing age-related diseases
- To Prevent Elderly Depression, Target Sleepon November 29, 2021 at 1:32 am
Maybe the best way to prevent depression in the elderly and others is to not talk about depression at all, but focus instead on a risk factor for depression—insomnia. Insomnia increases the risk for ...
- ‘The Long Good-Bye’; New Hope In The Battle Against Alzheimer’s Diseaseon November 28, 2021 at 7:12 pm
Tony Bennett sang about leaving his heart in San Francisco, and Sunday night the city’s heart was aching as CBS aired his final televised performance.
- Good News! Drinking Coffee May Lower Your Risk of Alzheimer’s Diseaseon November 28, 2021 at 10:38 am
Good news for those of us who can’t face the day without their morning flat white: a long-term study has revealed drinking higher amounts of coffee may make you less likely to develop Alzheimer’s ...
- The 4 Main Asbestos-Related Diseases you don’t want to ignoreon November 26, 2021 at 4:44 am
Although less common today, the fact remains that a whopping 39,000+ Americans die of asbestos-related diseases every year. Over the years, we’ve seen cases of people developing asbestos-related ...
- Age, sex and waning COVID-19 antibodieson November 19, 2021 at 1:42 pm
As widely-anticipated decisions about COVID-19 vaccine boosters roll out from U.S. agencies today, insights from an independent study underscore why boosters are important for all adults.
- Food Rx: Two Neurologists Share What They Eat in Hopes of Heading Off Alzheimer’s Diseaseon November 17, 2021 at 4:00 pm
Neurologists Ayesha and Dean Sherzai explain why they follow a plant-based diet and describe some of their favorite dishes.
- Season's first flu-related death in South Carolina is in Upstateon November 17, 2021 at 7:56 am
The season's first flu related death in South Carolina is in the Upstate, according to the South Carolina Department of Health and Environmental Control.
- Moderate Fish Intake May Help Prevent Blood Vessel Damage in Brainon November 15, 2021 at 2:31 pm
A new study suggests that eating fish may help prevent vascular disease in the brain, reducing the risk for cognitive problems.
- Risk of age-related diseases may be higher in younger b-cell non-hodgkin lymphoma survivors than in their older counterpartson November 3, 2021 at 12:28 am
They identified age-related disease outcomes through ... the U.S. Center for Disease Control and Prevention's National Program of Cancer Registries, the University of Utah, and the Huntsman ...
- Risk of age-related diseases may be higher in younger B-NHL survivors than in their older counterpartson November 3, 2021 at 12:20 am
Younger B-cell non-Hodgkin lymphoma (B-NHL) survivors had a higher relative risk of developing age-related diseases than older ... Biomarkers & Prevention, a journal of the American Association ...