For the first time, human embryonic stem cells have been transformed into nerve cells that helped mice regain the ability to learn and remember.
A study at UW-Madison is the first to show that human stem cells can successfully implant themselves in the brain and then heal neurological deficits, says senior author Su-Chun Zhang, a professor of neuroscience and neurology.
Once inside the mouse brain, the implanted stem cells formed two common, vital types of neurons, which communicate with the chemicals GABA or acetylcholine. “These two neuron types are involved in many kinds of human behavior, emotions, learning, memory, addiction and many other psychiatric issues,” says Zhang.
The human embryonic stem cells were cultured in the lab, using chemicals that are known to promote development into nerve cells — a field that Zhang has helped pioneer for 15 years. The mice were a special strain that do not reject transplants from other species.
After the transplant, the mice scored significantly better on common tests of learning and memory in mice. For example, they were more adept in the water maze test, which challenged them to remember the location of a hidden platform in a pool.
The study began with deliberate damage to a part of the brain that is involved in learning and memory.
Three measures were critical to success, says Zhang: location, timing and purity. “Developing brain cells get their signals from the tissue that they reside in, and the location in the brain we chose directed these cells to form both GABA and cholinergic neurons.”
The initial destruction was in an area called the medial septum, which connects to the hippocampus by GABA and cholinergic neurons. “This circuitry is fundamental to our ability to learn and remember,” says Zhang.
The transplanted cells, however, were placed in the hippocampus — a vital memory center — at the other end of those memory circuits. After the transferred cells were implanted, in response to chemical directions from the brain, they started to specialize and connect to the appropriate cells in the hippocampus.
The process is akin to removing a section of telephone cable, Zhang says. If you can find the correct route, you could wire the replacement from either end.
The Latest Bing News on:
Stem cell transplant
- Wiskott Aldrich syndrome: healthcare utilizations and disparities in transplant careon February 25, 2021 at 6:10 am
Wiskott Aldrich syndrome (WAS) is a rare disease and hematopoietic stem cell transplant (HCT) is considered the treatment modality of choice for WAS. We conducted a cross-sectional analysis on the ...
- Pediatric Stem Cell Transplantation Expert and Industry Leader Dr. Joseph Rosenthal Joins Cell Source's Scientific Advisory Boardon February 25, 2021 at 3:40 am
Cell Source, Inc. (OTC: CLCS) ("Cell Source" or the "Company"), a developer of Veto Cell-based innovative immunotherapy technologies that facilitate mismatched donor stem cell (e.g. bone marrow) and ...
- The Challenge’s Ashley Cain Says Daughter’s Cancer Has Returned After Stem Cell Transplant: ‘Blindsided’on February 24, 2021 at 6:44 am
The Challenge’ alum Ashley Cain found out about daughter Azaylia’s relapse the day she left the hospital — details ...
- Worldwide Industry for Cell Therapy Biomanufacturing to 2025 - Key Market Trends and Challengeson February 23, 2021 at 1:02 pm
This research report presents an in-depth analysis of the global cell therapy biomanufacturing market by product type, application and region. The report discusses the key inhibitors to the growth of ...
- Autologous Stem Cell and Non-Stem Cell Based Therapies Market Research Report by Manufacturers, Region, Type and Application, Forecast to 2026on February 22, 2021 at 5:08 am
Feb (Heraldkeepers) -- Autologous stem-cell transplantation (also called autogenetic, autogenic, or autogenic stem-cell transplantation or ...
- Anthony Nolan Cell & Gene Therapy Services and ONK Therapeutics Announce Collaborationon February 22, 2021 at 5:00 am
Cell therapy company ONK Therapeutics and blood cancer charity Anthony Nolan have entered into a collaboration to facilitate the development of the ne ...
- The impact of graft cell source on bloodstream infection in the first 100 days after allogeneic hematopoietic cell transplantationon February 19, 2021 at 10:09 am
Bloodstream infection (BSI) is a major infectious complication after allogeneic hematopoietic cell transplantation (HCT). To clarify the impact of graft cell source on the incidence of BSI after ...
- A brave girl of four battling a rare form of blood cancer could get a stem cell transplant from a coronavirus patienton February 18, 2021 at 12:57 pm
A BRAVE girl of four battling a rare form of blood cancer could get a stem cell transplant from a coronavirus patient. Adeline Davidson’s parents Steph, 26, and Jordan, 28, say they’ll con-sider ...
- Associating Baseline PROs and Complications of Stem Cell Transplanton February 16, 2021 at 11:30 am
Thank you so much for the chance to talk a little bit about our work, looking at baseline patient-reported outcomes and their association with complications of hematopoietic stem cell transplant or ...
- Campaign calls for more Black stem cell donors in order to save liveson February 15, 2021 at 6:00 pm
A new campaign aims to spread the message that a quick cheek swab can save the life of somehow who needs a stem cell transplant — especially if you're Black.
The Latest Google Headlines on:
Stem cell transplant
The Latest Bing News on:
Regaining the ability to learn and remember
- How will cybersecurity change with a new US president? Pros identify the biggest needson February 28, 2021 at 12:32 pm
Every new presidential administration brings change, one way or another. Learn what President Joseph Biden is facing on the cybersecurity front, along with some tips for government and businesses.
- Sharing more than genes: Father, son sustain traumatic brain injuries 10 years apart, find the road to recoveryon February 27, 2021 at 12:00 am
But their similarities go even further: they both suffered traumatic brain injuries in accidents 10 years apart. Merlyn Frank grew up in Northern California where he played football and baseball in ...
- Brooke Shields on Recovering from Broken Femur: 'Every Day I Feel Like I'm Having to Begin Again'on February 26, 2021 at 7:09 am
Despite her injury, the actress, who is partnering with Colgate on its new Renewal toothpaste, is determined to stay positive — and smiling — on her road to recovery ...
- Learning From the New Deal—For the Next Recoveryon February 22, 2021 at 6:37 pm
More Keynes and New Deal, less balanced-budget amendment. “I have a sense that we’re moving toward an environment where there’s broader support for public spending,” he said. “And that is exactly what ...
- Kevin Mather trampled the Mariners seeds of hopeon February 22, 2021 at 8:00 am
No MLB organization was less deserving of faith and goodwill. Then their president torched what little had regrown.
- What Near-Death Experiences Teach Us About the Brainon February 18, 2021 at 6:37 am
In his new book, After, he describes the truck driver’s near-death experience (NDE) and many others like it. Greyson spoke with both the truck driver and with his surgeon, and he tried to pin down the ...
- Our Neo-Gnostic Worldon February 16, 2021 at 9:11 am
Now the whole world groans, and is astonished to find itself Gnostic. Over on my subscriber-only Substack ( become a subscriber here ), I’ve been talking about modern Gnosticism. I recently read an ...
- Previewing the Arizona Diamondbacks farm system in 2021: Who are the top guys?on February 15, 2021 at 11:00 am
Listing the top prospects in the D-backs farm system that we should care the most about over the next three to five years.
- Psychology Todayon January 15, 2021 at 6:29 am
It provides a valuable lesson in the brain’s ability to heal even after unspeakable ... what allowed Morrow to use it to help Giffords re-learn how to speak. Unlike speech, which is concentrated ...