Caenorhabditis elegans, a model species of roundworm
Roundworms can not only combat obesity but ameliorate related metabolic disorders
Researchers at the University of Maryland School of Medicine, Baltimore, have shown in a mouse model that infection with nematodes (also known as roundworms) can not only combat obesity but ameliorate related metabolic disorders. Their research is published ahead of print online in the journal Infection and Immunity.
Gastrointestinal nematodes infect approximately 2 billion people worldwide, and some researchers believe up until the 20th century almost everyone had worms. In developed countries there is a decreasing incidence of nematode infection but a rising prevalence of certain types of autoimmunity, suggesting a relationship between the two. Nematode infection has been purported to have therapeutic effects and currently clinical trials are underway to examine worms as a treatment for diseases associated with the relevant cytokines, including inflammatory bowel disease, multiple sclerosis, and allergies.
In the study researchers tested the effect of nematode infection on mice fed a high-fat diet. Infected mice of normal girth gained 15 percent less weight than those that were not infected. Mice that were already obese when infected lost roughly 13 percent of their body weight within 10 days. Infection also drastically lowered fasting blood glucose, a risk factor for diabetes, and reduced fatty liver disease, decreasing liver fat by ~25 percent, and the weight of the liver by 30 percent.
The levels of insulin and leptin also dropped, “indicating that the mice restored their sensitivities to both hormones,” says corresponding author Aiping Zhao of the University of Maryland School of Medicine, Baltimore. Leptin moderates appetite. As with too much insulin, too high a level of leptin results in insensitivity, thus contributing to obesity and metabolic syndrome, Zhao explains.
The Latest Bing News on:
Roundworms
- Veterinary Parasiticides Global Market Report 2022on May 26, 2022 at 2:51 am
Major players in the veterinary parasiticides market are Bayer AG, Zoetis, Boehringer Ingelheim, Merck, Eli Lilly and Company, Virbac, Ceva Animal Health, Inc. , Merial, Perrigo Company, and ...
- What is Sea Moss Good For?on May 25, 2022 at 12:41 pm
What is Sea Moss Good For?
- 3 Preventable Reasons Cats End Up In The ER, According To An Emergency Veton May 25, 2022 at 8:21 am
Rushing your cat to the emergency room is super scary and stressful — it’s definitely something you want to avoid if you can help it. Well, some pretty common things that can land your cat in the ...
- Tricks to avoid infective diarrhoeaon May 24, 2022 at 2:33 pm
Poor hygiene, lack of sterilisation of food, unfiltered, contaminated drinking water as well as infrequent and ineffective handwashing techniques add to the problem ...
- Northwestern University: Male pheromones improve health of females’ eggson May 22, 2022 at 8:02 pm
Male pheromones just might be the fountain of youth for aging female animals’ eggs, according to a new Northwestern University study. In the new study, researchers used the tiny transparent roundworm ...
- Chris Ellis: In spring wildlife encounters, just let them beon May 21, 2022 at 9:07 am
I dedicate a column to the encounters with wildlife during this active-wildlife-encounter time of year in the Mountain State.
- Can You Take Ivermectin with Type 1 Diabetes?on May 20, 2022 at 1:00 am
Ivermectin is an oral, prescription medication that some have used for treating COVID-19 despite FDA warnings.
- Male pheromones improve health of females' eggson May 19, 2022 at 1:33 pm
New study on roundworms finds that exposure to male pheromones slows down aging of female eggs. Pheromone exposure decreased offspring death and chromosomal abnormalities by twofold. Male ...
- Male pheromones may be the fountain of youth for aging females' eggson May 18, 2022 at 5:01 pm
elegans, a well-established model organism commonly used in biology research. Exposure of female roundworms to male pheromones slowed down the aging of the females' egg cells, resulting in ...
- New research finds that male pheromones may improve health of females' eggson May 18, 2022 at 5:01 pm
Shifting energy to reproduction To conduct the study, the team aged female roundworms in the presence of a pheromone that is normally produced by male roundworms. The researchers saw that egg ...
The Latest Google Headlines on:
Roundworms
[/vc_column_text]
The Latest Bing News on:
Obesity and metabolic syndrome
- Covid-19, obesity and North Korea: a lesson for Hong Kong?on May 25, 2022 at 8:30 pm
Readers discuss the link between Covid-19 and metabolic syndrome, the revamp of the Hong Kong government, and LGBTQ rights in South Korea Feel strongly about these letters, or any other aspects of the ...
- Endoscopic Sleeve Gastroplasty Boosts Weight-Loss Outcomeson May 25, 2022 at 11:33 am
Patients with obesity who underwent endoscopic sleeve gastroplasty (ESG) along with lifestyle changes experienced more weight loss compared to lifestyle changes alone, and they also saw improvements ...
- Subtle Signs Your Blood Sugar is Too Highon May 23, 2022 at 4:45 am
I am also board-certified in obesity medicine. My practice primarily focuses on general endocrinology which includes many patients with both type one and type two diabetes as well as pre-diabetes, ...
- Metabolic Syndromeon May 12, 2022 at 5:00 pm
Type-2 diabetes, raised blood-pressure, high cholesterol levels, obesity and high stress-levels are common conditions these days. A few simple changes in lifestyle can help you reduce your risk of ...
- Metabolic Syndrome in Rheumatoid Arthritison May 8, 2022 at 5:00 pm
Background Metabolic syndrome, a cluster of classical cardiovascular risk factors, including hypertension, obesity, glucose intolerance, and dyslipidemia is highly prevalent in patients with ...
- Diabetes, metabolic syndrome and obesityon May 7, 2022 at 4:59 pm
The Effectiveness of a Self-Efficacy-Focused Structured Education Program (SSEP) in Improving Metabolic Control and ... Energy Diets in the Treatment of Obesity and Type 2 Diabetes in Youth.
- Metabolic Syndromeon May 3, 2022 at 5:00 pm
A new study being presented at the European Congress on Obesity (ECO ... with an increased risk of cardiovascular disease, metabolic syndrome, and other health complications—whereas ...
- Metabolic Syndromeon April 19, 2022 at 5:00 pm
Metabolic syndrome increases a person's risk for diabetes, heart disease, and stroke, and includes conditions such as obesity, high blood pressure and high blood sugar. In a recent mouse-model stu ...
- Researchers identify a new treatment for metabolic syndromeon April 11, 2022 at 8:28 am
CLEVELAND—Metabolic syndrome increases a person’s risk for diabetes, heart disease, and stroke, and includes conditions such as obesity, high blood pressure and high blood sugar. In a recent ...
- Obesity and the Metabolic Syndrome in Children and Adolescentson February 13, 2022 at 5:17 am
We examined the effect of varying degrees of obesity on the prevalence of the metabolic syndrome and its relation to insulin resistance and to C-reactive protein and adiponectin levels in a large ...
