Gene Signature May Predict Response To Cancer Chemotherapy

Gene-Signature-May-Predict-Response-To-Cancer-Chemotherapy

An eight gene ‘signature’ can predict length of relapse-free survival after chemotherapy, according to new research from Taiwan.

In a study published in the journal BMC Medicine, Researchers from Academia Sinica and the National Taiwan University College of Medicine first identified genes that were involved in cellular invasion, a property of many cancer cells, using the National Cancer Institute’s 60 human cancer cell line panel (NCI-60).

By comparing the pattern of activation of each of these genes in different cell lines with how these cell lines responded to 99 different anti-cancer drugs, the researchers narrowed down the list of genes to just those which could potentially influence the outcome of chemotherapy.

The eight-gene signature featured the cancer hallmark gene, epidermal growth factor receptor (EGFR), and genes involved in cell adhesion, migration, invasion, tumor growth, and progression.

In clinical studies, they found that patients with lung and breast cancer whose gene signature put them in the low-risk group had a longer relapse free survival than the high-risk group.

The Latest Bing News on:

Cancer Chemotherapy

AI to Predict the Success of Chemotherapy in Breast Cancer
on February 8, 2023 at 8:27 am
At the University of Waterloo, engineers have come up with artificial intelligence (AI) technology to forecast if women with breast cancer would benefit from chemotherapy before surgery.
Tumor DNA May Predict Outcomes to Presurgical Treatment in Patients with Bladder Cancer
on February 8, 2023 at 8:00 am
Data suggests an association between tumor DNA circulating in plasma and patient responses to neoadjuvant treatment.
Man, 57, noticed growth on the side of his tongue ‘one month’ before dying of bowel cancer
on February 8, 2023 at 7:29 am
The case study marks a unique instance where bowel cancer cells have broken away from an original tumour and travelled to the oral cavity.
Clonal hematopoiesis may be more common among pediatric cancer survivors than the general population
on February 8, 2023 at 6:13 am
Researchers identified a higher rate of clonal hematopoiesis (CH) and prevalence of treatment-induced STAT3 gene mutations in blood samples from a large cohort of survivors of pediatric cancer, ...
Pierre Fabre comercializará y distribuirá EBVALLO® (tabelecleucel) (2)
on February 8, 2023 at 4:32 am
- Pierre Fabre comercializará y distribuirá la primera inmunoterapia con células T alogénicas aprobada en Europa tras la transferencia de la Autorización de Comercialización de la Comisión Europea de ...
AI can predict chemotherapy effectiveness
on February 8, 2023 at 2:44 am
Engineers in Canada have developed artificial intelligence (AI) technology to predict if women with breast cancer would benefit from chemotherapy prior to surgery.
AI can predict the effectiveness of breast cancer chemotherapy
on February 8, 2023 at 12:46 am
Engineers at the University of Waterloo have developed artificial intelligence (AI) technology to predict if women with breast cancer would benefit from chemotherapy prior to surgery. The new AI ...
Artificial intelligence to detect effectiveness of breast cancer chemotherapy: Study
on February 7, 2023 at 10:01 pm
With knowledge gleaned from CDI images of old breast cancer cases and information on their outcomes, the AI can predict if pre-operative chemotherapy treatment would benefit new patients based on ...
Drug study seeks to combat ovarian cancer chemotherapy
on February 7, 2023 at 5:18 pm
"If we are able to apply this combination therapy to ovarian cancer then the toxicity of current chemotherapy is avoided - resulting in the patient not feeling anywhere near as ba ...
AI can predict the effectiveness of neoadjuvant chemotherapy in breast cancer patients
on February 7, 2023 at 8:24 am
Engineers at the University of Waterloo have developed artificial intelligence (AI) technology to predict if women with breast cancer would benefit from chemotherapy prior to surgery.

The Latest Google Headlines on:

Cancer Chemotherapy

[google_news title=”” keyword=”Cancer Chemotherapy” num_posts=”10″ blurb_length=”0″ show_thumb=”left”]

[/vc_column_text]

The Latest Bing News on:

Gene Signature

Newly identified gene signature helps assess cancer risk and optimize treatment
on February 7, 2023 at 1:09 am
In a paper published in PNAS, Maureen Murphy, Ph.D., Deputy Director of Wistar's Ellen and Ronald Caplan Cancer Center and Ira Brind Professor and Program Leader in the Molecular & Cellular ...
The Wistar Institute: Wistar Scientists Identify a Gene Signature to Assess Cancer Risk in People
on February 6, 2023 at 1:00 pm
New research finds gene signature that distinguishes between disease-causing and benign variants of tumor suppressor protein P53PHILADELPHIA, Feb. 06, 2023, Deputy Director of Wistar's Ellen and Ronal ...
Wistar Scientists Identify a Gene Signature to Assess Cancer Risk in People
on February 6, 2023 at 12:45 pm
New research finds gene signature that distinguishes between disease-causing and benign variants of tumor suppressor protein P53PHILADELPHIA, Feb. 06, 2023 (GLOBE NEWSWIRE) -- In a paper published in ...
Scientists identify a gene signature to assess cancer risk in people
on February 6, 2023 at 12:00 pm
In a paper published in PNAS, Maureen Murphy, Ph.D., Deputy Director of Wistar's Ellen and Ronald Caplan Cancer Center and Ira Brind Professor and Program Leader in the Molecular & Cellular ...
Gene Therapy
on February 5, 2023 at 4:00 pm
Among the drugs Roche recorded impairment charges on are four gene therapies acquired in the company's 2019 deal for Spark Therapeutics. Against a stormy backdrop, 2022 did bring bright spots in ...
‘The Recruit’ Executive Producer Gene Klein Joins P3 Media Production Banner as Partner
on February 1, 2023 at 5:00 am
Producer Gene Klein has joined P3 Media, the production banner behind Netflix’s “The Recruit,” as a partner. Klein will lead development efforts for the company formed in 2018 by ...
Molecular endotypes of type 1 and type 2 SLE
on January 31, 2023 at 8:26 pm
Beyond the IFN gene signature, expression of other specific gene modules was shown to be useful in distinguishing type 1 and type 2 SLE activity. These findings were validated using a number of ...
Ampel BioSolutions, Duke Researchers Establish Fibromyalgia Gene Signature
on January 31, 2023 at 10:36 am
The fibromyalgia signature in particular will form the basis of the ... Science & Medicine and used whole-transcriptome sequencing to compare the differences in gene signatures between molecular ...
Descubren los genes que hicieron gigantes a las ballenas
on January 20, 2023 at 10:20 am
Un estudio publicado en 'Scientific Reports' revela los genes que probablemente permitieron a las ballenas crecer hasta tamaños gigantescos en comparación con sus antepasados. Los hallazgos ...
Hay genes dominantes y recesivos
on January 18, 2023 at 5:37 am
Los genes pueden o no expresarse, por la dominancia que contengan dependiendo de la mezcla de genes que los progenitores hayan aportado Alina Gabriela Monroy-Gamboa y ...