Gene-Signature-May-Predict-Response-To-Cancer-Chemotherapy
An eight gene ‘signature’ can predict length of relapse-free survival after chemotherapy, according to new research from Taiwan.
An eight gene ‘signature’ can predict length of relapse-free survival after chemotherapy, according to new research from Taiwan.
In a study published in the journal BMC Medicine, Researchers from Academia Sinica and the National Taiwan University College of Medicine first identified genes that were involved in cellular invasion, a property of many cancer cells, using the National Cancer Institute’s 60 human cancer cell line panel (NCI-60).
By comparing the pattern of activation of each of these genes in different cell lines with how these cell lines responded to 99 different anti-cancer drugs, the researchers narrowed down the list of genes to just those which could potentially influence the outcome of chemotherapy.
The eight-gene signature featured the cancer hallmark gene, epidermal growth factor receptor (EGFR), and genes involved in cell adhesion, migration, invasion, tumor growth, and progression.
In clinical studies, they found that patients with lung and breast cancer whose gene signature put them in the low-risk group had a longer relapse free survival than the high-risk group.
The Latest Bing News on:
Cancer Chemotherapy
- Cancer came for Cathedral senior, then for his lacrosse coach. It can't stop either one.on May 20, 2022 at 2:01 am
In a matter of weeks, Andrew Kinder went from the fastest player on the lacrosse field to laying in a hospital bed, battling leukemia.
- Dover grandmother writes children's book to make her cancer less scary for grandkidson May 20, 2022 at 2:00 am
Barbara Burgess wrote a children's book, illustrated by her son Joel, to help make her cancer a little less scary for her grandchildren. Burgess, 71, said after she was diagnosed in May 2019 and began ...
- Riding the waves off Nova Scotia, this surfer says she felt cancer-freeon May 20, 2022 at 2:00 am
Just over a month after a double mastectomy, Amber Spurrell of Dartmouth was back on her surfboard. The ocean served as therapy after a diagnosis of stage 2 breast cancer, says the Dartmouth woman.
- Breast cancer: Who can avoid chemotherapy post-surgery?on May 19, 2022 at 6:00 pm
When 36-year old Ritu was diagnosed with breast cancer, she was devastated thinking about the toll that chemotherapy would have on her physical and mental health. Fortunately, her doctor recommended a ...
- Feds advance proposal to cover uterine cancer treatment for 9/11 survivorson May 19, 2022 at 8:11 am
Adding the condition to the World Trade Center Health Program would cost about $2M annually between 2022 and 2025, officials say ...
- Identifying DNA repair genes holds promise for improving cancer treatmenton May 19, 2022 at 8:08 am
A new way in which cancer cells can repair DNA damage has been discovered by researchers at the University of Birmingham.
- Baish Collaborates on Research to Improve Cancer Tumor Treatment Outcomeson May 19, 2022 at 7:38 am
A Bucknell biomedical engineering professor is part of an international research team working to make chemotherapy more effective for cancer patients. The researchers have used mathematical modeling ...
- How Cancer Treatment Is Improving for People Living in Rural Areason May 19, 2022 at 7:04 am
New groups are working to bring improved cancer care to those in rural areas through the use of new technology and programs.
- A woman who had IVF before her cancer treatment donated her frozen embryos to a fellow survivor, giving her the chance to be a momon May 19, 2022 at 4:16 am
After two survivors of cervical cancer bonded online, the woman who'd had IVF donated her leftover embryos to her new friend.
- Isabl’s rapid whole-genome analysis opens the playbook for cancer treatmenton May 18, 2022 at 9:55 am
Every cancer is unique because every person is unique, and one of the most important weapons in any cancer battle is information. Isabl offers that in abundance through rapid sequencing of cancer ...
The Latest Google Headlines on:
Cancer Chemotherapy
[/vc_column_text]
The Latest Bing News on:
Gene Signature
- Molecular profiling of diseased joints could transform treatment for rheumatoid arthritis patientson May 19, 2022 at 5:24 pm
New research from Queen Mary University of London, published in Nature Medicine, has shown that molecular profiling of the diseased joint tissue can significantly impact whether specific drug ...
- Pee pals: Dolphins taste friends' urine to know they're aroundon May 18, 2022 at 12:36 pm
Think about people you know, and how you could tell they were around even if you couldn't see them: perhaps their voice, or a favored perfume.
- Researchers identify tumor-based methylation patterns as cancer biomarkerson May 18, 2022 at 10:35 am
Biomarkers are often used during the management of cancer to guide treatment decisions and predict patient outcomes. However, it is often difficult to identify appropriate biomarkers that that can be ...
- Study identifies cancer biomarkers based on a type of genetic modificationon May 18, 2022 at 9:25 am
Biomarkers are often used during the management of cancer to guide treatment decisions and predict patient outcomes. However, it is often difficult to identify appropriate biomarkers that can be ...
- Targeting interleukin-6 could help relieve immunotherapy side effectson May 9, 2022 at 8:01 am
Furthermore, the IL-6 gene signature was upregulated in those whose tumors did not respond to immunotherapy, but the increased levels were not seen in responders. Based on this observation ...
- Misconceptions Remain on Gene Signature Use in Breast Canceron May 4, 2022 at 5:01 pm
Overall, more than 70% of respondents agreed that identifying tumor intrinsic subtype via gene expression profiling was important in making prognostic and treatment decisions; however, a consensus ...
- KISS’ Gene Simmons and Gibson Unveil Signature G² Thunderbird Basson April 21, 2022 at 4:01 am
The post KISS’ Gene Simmons and Gibson Unveil Signature G² Thunderbird Bass appeared first on Consequence. KISS legend Gene Simmons and Gibson have launched their new line of signature guitars ...
- Gene-Expression Signatures in Breast Canceron April 20, 2022 at 4:59 pm
This distinction can be further refined by the application of a genomic grade, a gene-expression signature of tumor differentiation. 4,16 Luminal B tumors typically have a high genomic grade ...
- Novel 18-Gene Signature for Predicting Relapse in ER-Positive, HER2-Negative Breast Canceron August 27, 2021 at 10:04 am
Contrary to our hypothesis, the derived early and late signatures were not significantly more prognostic than the 18-gene 10-year signature. The 18-gene 10-year signature was internally validated ...
