A vaccine delivery system which can be administered via nasal spray, oral liquid, capsule, or small soluble film placed under the tongue
Taking the “ouch” out of injections is a worthy endeavor, but what if they could be avoided entirely? New research conducted at Royal Holloway, University of London offers the hope of achieving just this, by using a bacterium to deliver a vaccine which can be administered via nasal spray, oral liquid, capsule, or small soluble film placed under the tongue, thus reducing the risk of spreading infectious diseases like HIV.
The research, led by Professor Simon Cutting from the School of Biological Sciences at Royal Holloway, was conducted with the use of pro-biotic spores taken from the bacterium Bacillus subtilis, which Cutting cites as ideal vehicles for carrying antigens and promoting an immune response in the patient.
“Rather than requiring needle delivery, vaccines based on Bacillus spores can be delivered via a nasal spray, or as on oral liquid or capsule,” explained Cutting. “Alternatively they can be administered via a small soluble film placed under the tongue, in a similar way to modern breath fresheners. As spores are exceptionally stable, vaccines based on Bacillus do not require cold-chain storage alleviating a further issue with current vaccine approaches.”
via Gizmag – Adam Williams
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