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One of the latest attempts to boost the body’s defenses against cancer is called adoptive cell transfer, in which patients receive a therapeutic injection of their own immune cells.
This therapy, currently tested in early clinical trials for melanoma and neuroblastoma, has its limitations: Removing immune cells from a patient and growing them outside the body for future re-injection is extremely expensive and not always technically feasible.
Weizmann Institute scientists have now tested in mice a new form of adoptive cell transfer, which overcomes these limitations while enhancing the tumor-fighting ability of the transferred cells. The research, reported recently in Blood, was performed in the lab of Prof. Zelig Eshhar of the Institute’s Immunology Department, by graduate student Assaf Marcus and lab technician Tova Waks.
The new approach should be more readily applicable than existing adoptive cell transfer treatments because it relies on a donor pool of immune T cells that can be prepared in advance, rather than on the patient’s own cells. Moreover, using a method pioneered by Prof. Eshhar more than two decades ago, these T cells are outfitted with receptors that specifically seek out and identify the tumor, thereby promoting its destruction.
In the study, the scientists first suppressed the immune system of mice with a relatively mild dose of radiation. They then administered a controlled dose of the modified donor T cells. The mild suppression temporarily prevented the donor T cells from being rejected by the recipient, but it didn’t prevent the cells themselves from attacking the recipient’s body, particularly the tumor. This approach was precisely what rendered the therapy so effective: The delay in the rejection of the donor T cells gave these cells sufficient opportunity to destroy the tumor.
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Adoptive cell transfer
- Augmentation of Anti-tumor Immunity by Adoptive T-cell Transfer After Allogeneic Hematopoietic Stem Cell Transplantationon May 2, 2022 at 5:00 pm
Adoptive T-cell therapy after allogeneic hematopoietic ... after allogeneic HCT and are suitable for T-cell receptor gene transfer approaches. Several promising antigens are in clinical trials ...
- Augmentation of Anti-tumor Immunity by Adoptive T-cell Transfer After Allogeneic Hematopoietic Stem Cell Transplantationon May 1, 2022 at 5:01 pm
Key advances in the last few years include the identification of T-cell subsets with the potential for prolonged persistence following adoptive transfer and the technical ability to genetically ...
- Global Adoptive Cell Therapy Market (2022 to 2030) - Size, Share, Outlook, and Opportunity Analysison April 28, 2022 at 5:01 am
Adoptive cell therapy is also called T-cell transfer therapy, and cellular immunotherapy. Market Dynamics Key players operating in the global adoptive cell therapy market are focusing on adoption of ...
- Insights on the Adoptive Cell Therapy Global Market to 2030 - by Type, Application, End-user and Regionon April 28, 2022 at 4:49 am
Adoptive cell therapy is also called T-cell transfer therapy, and cellular immunotherapy. Key players operating in the global adoptive cell therapy market are focusing on adoption of growth ...
- Global Adoptive Cell Therapy Market (2022 to 2030) - Size, Share, Outlook, and Opportunity Analysison April 28, 2022 at 4:43 am
Adoptive cell therapy (ACT) is a type of immunotherapy in which T cells (a type of immune cell) are given to a patient to help the body fight diseases, such as cancer. Types o ...
- Worldwide Adoptive Cell Therapy Industry to 2030 - Featuring Novartis, Gilead Sciences and Cellectis Among Others - ResearchAndMarkets.comon April 25, 2022 at 11:32 am
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- Worldwide Adoptive Cell Therapy Industry to 2030 - Featuring Novartis, Gilead Sciences and Cellectis Among Others - ResearchAndMarkets.comon April 25, 2022 at 5:59 am
Adoptive cell therapy is also called T-cell transfer therapy, and cellular immunotherapy. Key players operating in the global adoptive cell therapy market are focusing on adoption of growth ...
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