In the quest to grow replacement human organs in the lab, livers are no doubt at the top of many a barfly’s wish list.
With its wide range of functions that support almost every organ in the body and no way to compensate for the absence of liver function, the ability to grow a replacement is also the focus of many research efforts. Now, for the first time, researchers have been able to successfully engineer miniature livers in the lab using human liver cells.
The ultimate aim of the research carried out at the Institute for Regenerative Medicine at Wake Forest University Baptist Medical Center is to provide a solution to the shortage of donor livers available for patients who need transplants. Additionally, the laboratory-engineered livers could also be used to test the safety of new drugs.
The livers engineered by the researchers are about an inch in diameter and weigh about 0.2 ounces (5.7 g). Even though the average weight of an adult human liver is around 4.4 pounds (2 kg), to meet to minimum needs of the human body the scientists say an engineered liver would need to weigh about one pound (454 g) because research has shown that human livers functioning at 30 percent of capacity are able to sustain the human body.
“We are excited about the possibilities this research represents, but must stress that we’re at an early stage and many technical hurdles must be overcome before it could benefit patients,” said Shay Soker, Ph.D., professor of regenerative medicine and project director. “Not only must we learn how to grow billions of liver cells at one time in order to engineer livers large enough for patients, but we must determine whether these organs are safe to use in patients.”